TRPC1 / STIM1

Interaction: TRPC1Detail bc8838fa5bd2464c5553a5a10de82d112f40db7d921ce377f414735e0504230c / STIM1Detail bc8838fa5bd2464c5553a5a10de82d112f40db7d921ce377f414735e0504230c
Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Screening Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Validation: In vitro validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Validation: In vivo validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Characterization Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Functional consequence Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b top
Screening Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPC1 STIM1 Inference Prediction 16906149
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Screening Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Validation: In vitro validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Validation: In vivo validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Characterization Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Functional consequence Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b top
Validation: In vitro validation Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Assay with recombinant proteins Reference
TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Expression system Species Region Expression system
TRPC1 STIM1 Fusion protein-pull down assay Not specified 1-347 E. coli Not used HSG cell lysates 17224452
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Screening Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Validation: In vitro validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Validation: In vivo validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Characterization Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Functional consequence Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b top
Validation: In vivo validation Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPC1 STIM1 Co-immunofluorescence staining HEK293 Human Full-length Human Full-length 16906149
TRPC1 STIM1 Co-immunofluorescence staining Mouse pulmonary arterial smooth muscle cell 23034388
TRPC1 STIM1 Co-immunofluorescence staining HSG cell Human Full-length Not specified Full-length 17224452
TRPC1 STIM1 Co-immunofluorescence staining HSG cell 19897728
TRPC1 STIM1 Co-immunofluorescence staining Human saphenous vein vascular smooth muscle cell 18802022
TRPC1 STIM1 Co-immunoprecipitation HEK293 Human Full-length Not used 19228695
TRPC1 STIM1 Co-immunoprecipitation Human platelets 16870612
TRPC1 STIM1 Co-immunoprecipitation Mouse pulmonary arterial smooth muscle cell 19332490
TRPC1 STIM1 Co-immunoprecipitation Rat brain tissue 16906149
TRPC1 STIM1 Co-immunoprecipitation HEK293 Human Full-length Human Full-length 16906149
TRPC1 STIM1 Co-immunoprecipitation Mouse pulmonary arterial smooth muscle cell 23034388
TRPC1 STIM1 Co-immunoprecipitation Human platelets 18249094
TRPC1 STIM1 Co-immunoprecipitation HEK293 Not specified Full-length Human Full-length 24464579
TRPC1 STIM1 Co-immunoprecipitation Mouse bone marrow derived macrophages 25013939
TRPC1 STIM1 Co-immunoprecipitation HEK293 18326500
TRPC1 STIM1 Co-immunoprecipitation HSG cell 18430726
TRPC1 STIM1 Co-immunoprecipitation HEK293 Not used Not specified Full-length 17224452
TRPC1 STIM1 Co-immunoprecipitation A7r5 Not used Not specified Full-length 17224452
TRPC1 STIM1 Co-immunoprecipitation Human platelets 18644792
TRPC1 STIM1 Co-immunoprecipitation HEK293 23395841
TRPC1 STIM1 Co-immunoprecipitation Human atrial myocyte 23686296
TRPC1 STIM1 Co-immunoprecipitation HSG cell 19897728
TRPC1 STIM1 Co-immunoprecipitation HEK293T Rat Full-length Rat Full-length 22201561
TRPC1 STIM1 Co-immunoprecipitation Human saphenous vein vascular smooth muscle cell 18802022
TRPC1 STIM1 Co-immunoprecipitation Human saphenous vein vascular smooth muscle cell Human Full-length Not specified Full-length 18802022
TRPC1 STIM1 Co-immunoprecipitation Human platelets 17892531
TRPC1 STIM1 Co-immunoprecipitation Human parathyroid tissue 20194530
TRPC1 STIM1 Co-immunoprecipitation SH-SY5Y 22446186
TRPC1 STIM1 Co-immunoprecipitation HSG cell 20488539
TRPC1 STIM1 Co-immunoprecipitation Rat normal small intestine cell line IEC-6 22592407
TRPC1 STIM1 Co-immunoprecipitation Rat normal small intestine cell line IEC-6 (IEC-Cdx2L1 stable cell) 22592407
TRPC1 STIM1 Co-immunoprecipitation Caco-2 cell 22592407
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Screening Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Validation: In vitro validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Validation: In vivo validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Characterization Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Functional consequence Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b top
Characterization Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Binding region mapping Stoichiometry Affinity (Kd) Reference
TRP channel Interactor
TRP channel Interactor Method Species Region Species Region
TRPC1 STIM1 Co-immunoprecipitation Human Not determined Human 251-535 16906149
TRPC1 STIM1 Co-immunoprecipitation Rat Not determined Rat 1798-1887 22201561
TRPC1 STIM1 Fusion protein-pull down assay Human Not determined Human 251-535 16906149
TRPC1 STIM1 Fusion protein-pull down assay Human 1-347 Human Not determined 17224452
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Screening Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Validation: In vitro validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Validation: In vivo validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Characterization Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Functional consequence Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b top
Functional consequence Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
TRP channel Interactor Method Post-translational modification Subcellular trafficking Activity Reference
TRPC1 STIM1 Patch clamp Activation 16906149
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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