TRPC1 / TRPP1

Interaction: TRPC1Detail / TRPP1Detail
Screening Toggle
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPC1 TRPP1 Inference Prediction 10097141
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Validation: In vitro validation Toggle
  Assay with recombinant proteins Reference
TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Expression system Species Region Expression system
TRPC1 TRPP1 Fusion protein-pull down assay Human 662-750 E. coli Human 680-968 In vitro translation 10097141
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Validation: In vivo validation Toggle
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPC1 TRPP1 Co-immunofluorescence staining HEK293T Human Full-length Human Full-length 10097141
TRPC1 TRPP1 Co-immunofluorescence staining HEK293 tsA 201 Human Full-length Human Full-length 19850920
TRPC1 TRPP1 Co-immunofluorescence staining mIMCD-3 18323855
TRPC1 TRPP1 Co-immunoprecipitation HEK293T Human Full-length Not specified Not specified 14530267
TRPC1 TRPP1 Co-immunoprecipitation Human glomerular mesangial cell Human Full-length Not used 18256307
TRPC1 TRPP1 Co-immunoprecipitation HEK293 Mouse Full-length Human Full-length 19812035
TRPC1 TRPP1 Co-immunoprecipitation HEK293 tsA 201 Human Full-length Human Full-length 19850920
TRPC1 TRPP1 Co-immunoprecipitation Rat kidney tissue 18323855
TRPC1 TRPP1 Co-immunoprecipitation HEK293 tsA 201 Human Full-length Human Full-length 20682256
TRPC1 TRPP1 Co-immunoprecipitation HEK293T Human Full-length Human Full-length 10097141
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Characterization Toggle
  Binding region mapping Stoichiometry Affinity (Kd) Reference
TRP channel Interactor
TRP channel Interactor Method Species Region Species Region
TRPC1 TRPP1 Atomic force microscopy(AFM) analysis 2:2 19850920
TRPC1 TRPP1 Atomic force microscopy(AFM) analysis 2:2 19193631
TRPC1 TRPP1 Co-immunoprecipitation Human Not determined Human 1-643 10097141
TRPC1 TRPP1 Co-immunoprecipitation Human Not determined Human 679-968 10097141
TRPC1 TRPP1 Yeast two-hybrid Human 639-750 Human 822-895 10097141
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Functional consequence Toggle
TRP channel Interactor Method Post-translational modification Subcellular trafficking Activity Reference
TRPC1 TRPP1 Patch clamp New channel creation 18323855
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TRP / Interactor

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