TRPM2 / PTPL1

Interaction: TRPM2Detail / PTPL1Detail
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Screening Toggle
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPM2 PTPL1 Inference Prediction 17251321
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Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Validation: In vivo validation Toggle
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPM2 PTPL1 Co-immunoprecipitation Human monocytic U937-ecoR cell 17251321
TRPM2 PTPL1 Co-immunoprecipitation HEK293T Human Full-length Human Full-length 17251321
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Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Characterization Toggle
  Binding region mapping Stoichiometry Affinity (Kd) Reference
TRP channel Interactor
TRP channel Interactor Method Species Region Species Region
TRPM2 PTPL1 Fusion protein-pull down assay Human Not determined Human 1099-1199 17251321
TRPM2 PTPL1 Fusion protein-pull down assay Human Not determined Human 1888-1990 17251321
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Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Functional consequence Toggle
TRP channel Interactor Method Post-translational modification Subcellular trafficking Activity Reference
TRPM2 PTPL1 Calcium measurement Inhibition 17251321
TRPM2 PTPL1 In vivo PTM assay Dephosphorylation 17251321
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TRP / Interactor

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