TRPML1 / TRPML3
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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Screening
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| Experimental screening | Non-experimental screening | Reference | |||||||
| TRP channel construct | Interactor source | ||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | ||
| TRPML1 | TRPML3 | Inference | Prediction | 16606612 | |||||
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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Validation: In vivo validation
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| Assay with endogenous proteins | Assay with overexpressed proteins | Reference | |||||||
| Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | ||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | |||
| TRPML1 | TRPML3 | Co-immunofluorescence staining | HEK293 | 19557826 | |||||
| TRPML1 | TRPML3 | Co-immunofluorescence staining | CHO | Human | Full-length | Human | Full-length | 19885840 | |
| TRPML1 | TRPML3 | Co-immunoprecipitation | HEK293 | Human | Full-length (mutation in the pore region) | Human | Full-length (mutation in the pore region) | 20736310 | |
| TRPML1 | TRPML3 | Co-immunoprecipitation | HEK293 | Not specified | Full-length | Human | Full-length | 19522758 | |
| TRPML1 | TRPML3 | Co-immunoprecipitation | HEK293 | 19557826 | |||||
| TRPML1 | TRPML3 | Co-immunoprecipitation | CHO | Human | Full-length | Human | Full-length | 19885840 | |
| TRPML1 | TRPML3 | Fluorescence resonance energy transfer | HEK293 | Human | Full-length | Mouse | Full-length | 16606612 | |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
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Functional consequence
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| TRP channel | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference | |||||
| TRPML1 | TRPML3 | Patch clamp | New channel creation | 19885840 | |||||||
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)




Screening