TRPV1 / Calmodulin

Interaction: TRPV1Detail / CalmodulinDetail
Screening Toggle
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPV1 Calmodulin Inference Prediction 12808128
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Validation: In vitro validation Toggle
  Assay with recombinant proteins Reference
TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Expression system Species Region Expression system
TRPV1 Calmodulin Fast performance liquid chromatography Rat 759-802 E. coli Human Full-length E. coli 23109716
TRPV1 Calmodulin Fast performance liquid chromatography Rat 712?838 E. coli Mouse Full-length E. coli 23119017
TRPV1 Calmodulin Fusion protein-pull down assay Rat N-terminus E. coli Not specified Full-length In vitro translation 14699077
TRPV1 Calmodulin Fusion protein-pull down assay Rat C-terminus E. coli Bovine Full-length Not specified 12808128
TRPV1 Calmodulin X-ray diffraction-structural analysis Rat 784-798 E. coli Human Full-length E. coli 23109716
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Validation: In vivo validation Toggle
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPV1 Calmodulin Co-immunoprecipitation HEK293 Rat Full-length Rat Full-length 12808128
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Characterization Toggle
  Binding region mapping Stoichiometry Affinity (Kd) Reference
TRP channel Interactor
TRP channel Interactor Method Species Region Species Region
TRPV1 Calmodulin Fast performance liquid chromatography Rat 712?838 Mouse Not determined 23119017
TRPV1 Calmodulin Fusion protein-pull down assay Rat ARD domain Not specified Not determined 20926660
TRPV1 Calmodulin Fusion protein-pull down assay Rat 189-222 Not specified Not determined 14699077
TRPV1 Calmodulin Fusion protein-pull down assay Human 101-364 Not specified Not determined 19864432
TRPV1 Calmodulin Fusion protein-pull down assay Rat 767-801 Bovine Not determined 12808128
TRPV1 Calmodulin X-ray diffraction-structural analysis Rat 784-798 Human 11-145 23109716
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Functional consequence Toggle
TRP channel Interactor Method Post-translational modification Subcellular trafficking Activity Reference
TRPV1 Calmodulin Patch clamp Inhibition 14699077
TRPV1 Calmodulin Patch clamp Sensitization 23109716
TRPV1 Calmodulin Patch clamp Inhibition 12808128
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TRP / Interactor

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