TRPV6 / Calmodulin

Interaction: TRPV6Detail / CalmodulinDetail
Screening Toggle
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPV6 Calmodulin Inference Prediction 11248124
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Validation: In vitro validation Toggle
  Assay with recombinant proteins Reference
TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Expression system Species Region Expression system
TRPV6 Calmodulin Fusion protein-pull down assay Human 584-725 In vitro translation Bovine Full-length E. coli 11248124
TRPV6 Calmodulin Fusion protein-pull down assay Rabbit Full-length In vitro translation Not specified Full-length Not specified 15123711
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Validation: In vivo validation Toggle
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPV6 Calmodulin Co-immunoprecipitation Xenopus oocyte Rabbit Full-length Not specified Full-length 15123711
TRPV6 Calmodulin Fluorescence resonance energy transfer HEK293 Rat Full-length Not specified Full-length 16959851
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Characterization Toggle
  Binding region mapping Stoichiometry Affinity (Kd) Reference
TRP channel Interactor
TRP channel Interactor Method Species Region Species Region
TRPV6 Calmodulin Fluorescence probe labeling 1:1 43 nM 12765696
TRPV6 Calmodulin Fluorescence probe labeling 65 nM 11248124
TRPV6 Calmodulin Fusion protein-pull down assay Human 691-711 Bovine Not determined 11248124
TRPV6 Calmodulin Fusion protein-pull down assay Human ARD domain Not specified Not determined 20926660
TRPV6 Calmodulin Fusion protein-pull down assay Rabbit 327-577 Not specified Not determined 15123711
TRPV6 Calmodulin Fusion protein-pull down assay Rabbit 88-97 Not specified Not determined 15123711
TRPV6 Calmodulin Fusion protein-pull down assay Rabbit 643-656 Not specified Not determined 15123711
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Functional consequence Toggle
TRP channel Interactor Method Post-translational modification Subcellular trafficking Activity Reference
TRPV6 Calmodulin Calcium measurement Inhibition 16959851
TRPV6 Calmodulin Patch clamp Inhibition 11248124
TRPV6 Calmodulin Patch clamp Inhibition 15123711
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TRP / Interactor

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