TRPV6 / S100A10

Interaction: TRPV6Detail / S100A10Detail
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Screening Toggle
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPV6 S100A10 Inference Prediction 12660155
TRPV6 S100A10 Yeast two-hybrid Human Not specified Human Not specified Not specified 16189514
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Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Validation: In vitro validation Toggle
  Assay with recombinant proteins Reference
TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Expression system Species Region Expression system
TRPV6 S100A10 Fusion protein-pull down assay Mouse Full-length E. coli Mouse Full-length Xenopus oocyte lysates 12660155
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Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Validation: In vivo validation Toggle
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPV6 S100A10 Co-immunofluorescence staining Rat duodenum tissue 12660155
TRPV6 S100A10 Co-immunoprecipitation Caco-2 cell 18187190
TRPV6 S100A10 Co-immunoprecipitation Human 16HBE14o- cell 18187190
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Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Characterization Toggle
  Binding region mapping Stoichiometry Affinity (Kd) Reference
TRP channel Interactor
TRP channel Interactor Method Species Region Species Region
TRPV6 S100A10 Fusion protein-pull down assay Mouse 597-601 Mouse Not determined 12660155
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Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Functional consequence Toggle
TRP channel Interactor Method Post-translational modification Subcellular trafficking Activity Reference
TRPV6 S100A10 Co-immunofluorescence staining Increase in plasma membrane level 12660155
TRPV6 S100A10 Patch clamp Activation 12660155
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TRP / Interactor

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