α-actinin-4 / TRP channels

Name: Alpha-actinin-4 (α-actinin-4)
Official Symbol: ACTN4 provided by HGNC
Function:
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).
Species External DB Questionmark
Entrez Gene UniprotKB DIP IntAct MINT BioGRID STRING IUPHAR-DB KEGG OMIM
Human
Seq		 81External O43707External DIP-33179NExternal O43707External MINT-4998602External 106596External O43707External   hsa:81External 604638External
Mouse
Seq		 60595External P57780External DIP-31933NExternal P57780External MINT-136628External 208624External P57780External   mmu:60595External  
Rat
Seq		 63836External Q9QXQ0External DIP-36800NExternal Q9QXQ0External MINT-1775108External 248895External Q9QXQ0External   rno:63836External  
PPI pairs:
Biological Process:
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Screening Toggle
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPC5 Link α-actinin-4 Affinity purification-mass spectrometry Endogenous protein Rat Brain Cerebral cortex lysates 16025302
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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