α2-actin / TRP channels
Name: Actin, aortic smooth muscle
(α2-actin)
Official Symbol: ACTA2
provided by HGNC
Function:
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
![]() |
59 |
P62736 |
DIP-33450N |
P62736 |
UNK-5382037 |
106574 |
P62736 |
hsa:59 |
102620 |
|
Mouse
![]() |
11475 |
P62737 |
P62737 |
MINT-4086753 |
197952 |
P62737 |
mmu:11475 |
|||
Rat
![]() |
81633 |
P62738 |
DIP-37341N |
P62738 |
249533 |
P62738 |
rno:81633 |
|||
PPI pairs:
Biological Process:
- GO:0072144
: glomerular mesangial cell development - GO:0009615
: response to virus
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:102620
:
Aortic aneurysm, familial thoracic 6
(OMIM:611788
)
- OMIM:102620
:
Multisystemic smooth muscle dysfunction syndrome
(OMIM:613834
)
- OMIM:102620
:
Moyamoya disease 5
(OMIM:614042
)
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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top
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Screening
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|---|---|---|---|---|---|---|---|---|---|---|
| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPC5 |
|
α2-actin | Affinity purification-mass spectrometry | Endogenous protein | Rat | Brain | Cerebral cortex lysates | 16025302 | ||
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)






Screening