β-Trcp1 / TRP channels

Name: F-box/WD repeat-containing protein 1A (β-Trcp1)
Official Symbol: BTRC provided by HGNC
Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, SMAD3, SMAD4, CDC25A, DLG1, FBXO5 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of phosphorylated SNAI1. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).
Species External DB Questionmark
Entrez Gene UniprotKB DIP IntAct MINT BioGRID STRING IUPHAR-DB KEGG OMIM
Human
Seq
8945External Q9Y297External DIP-31607NExternal Q9Y297External MINT-108636External 114457External Q9Y297External   hsa:8945External 603482External
Mouse
Seq
12234External Q3ULA2External   Q3ULA2External UNK-5414274External 198403External Q3ULA2External   mmu:12234External  
Rat
Seq
361765External Q5U4E5External     UNK-5455825External 262937External Q5U4E5External   rno:361765External  
PPI pairs:
Biological Process:
  • GO:0031145 External : anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • GO:0060444 External : branching involved in mammary gland duct morphogenesis
  • GO:0071407 External : cellular response to organic cyclic compound
  • GO:0033598 External : mammary gland epithelial cell proliferation
  • GO:0043433 External : negative regulation of sequence-specific DNA binding transcription factor activity
  • GO:0045879 External : negative regulation of smoothened signaling pathway
  • GO:0045892 External : negative regulation of transcription, DNA-dependent
  • GO:0042753 External : positive regulation of circadian rhythm
  • GO:0045862 External : positive regulation of proteolysis
  • GO:0045893 External : positive regulation of transcription, DNA-dependent
  • GO:0051437 External : positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  • GO:0006470 External : protein dephosphorylation
  • GO:0031648 External : protein destabilization
  • GO:0000209 External : protein polyubiquitination
  • GO:0016567 External : protein ubiquitination
  • GO:0051726 External : regulation of cell cycle
  • GO:0043122 External : regulation of I-kappaB kinase/NF-kappaB cascade
  • GO:0061136 External : regulation of proteasomal protein catabolic process
  • GO:0007165 External : signal transduction
  • GO:0016032 External : viral reproduction
  • GO:0019048 External : virus-host interaction
  • GO:0016055 External : Wnt receptor signaling pathway
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
Screening Toggle
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPP1 Link β-Trcp1 Inference Prediction 17636028
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Validation: In vivo validation Toggle
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPP1 Link β-Trcp1 Co-immunoprecipitation HEK293 Mouse Full-length Mouse Full-length 17636028
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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