β-catenin / TRP channels

Name: Catenin beta-1 (β-catenin)
Official Symbol: CTNNB1 provided by HGNC
Function:
Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).
Species External DB Questionmark
Entrez Gene UniprotKB DIP IntAct MINT BioGRID STRING IUPHAR-DB KEGG OMIM
Human
Seq		 1499External P35222External DIP-122NExternal P35222External MINT-105089External 107880External P35222External   hsa:1499External 116806External
Mouse
Seq		 12387External Q02248External DIP-31560NExternal Q02248External MINT-103426External 198512External Q02248External   mmu:12387External  
Rat
Seq		 84353External Q9WU82External DIP-37053NExternal Q9WU82External MINT-87458External 249913External Q9WU82External   rno:84353External  
PPI pairs:
Biological Process:
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Screening Toggle
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPC4 Link β-catenin Inference Prediction 19996314
TRPV4 Link β-catenin Yeast two-hybrid Mouse N-terminus Human Keratinocyte cDNA library 20413591
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Validation: In vivo validation Toggle
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPC4 Link β-catenin Co-immunofluorescence staining HEK293 Mouse Full-length Not specified Full-length 19996314
TRPC4 Link β-catenin Co-immunoprecipitation Human microvascular endpthelial cell-1 Mouse Full-length Not specified Full-length 19996314
TRPC4 Link β-catenin Fluorescence resonance energy transfer HEK293 Mouse Full-length Not specified Full-length 19996314
TRPV4 Link β-catenin Co-immunoprecipitation HEK 22374181
TRPV4 Link β-catenin Co-immunoprecipitation MDCK 20413591
TRPV4 Link β-catenin Co-immunoprecipitation COS-7 Mouse Full-length Not specified Not specified 20413591
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Characterization Toggle
  Binding region mapping Stoichiometry Affinity (Kd) Reference
TRP channel Interactor
TRP channel Interactor Method Species Region Species Region
TRPV4 Link β-catenin Co-immunoprecipitation Mouse Not determined Not specified Not determined 20413591
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Functional consequence Toggle
TRP channel Interactor Method Post-translational modification Subcellular trafficking Activity Reference
TRPC4 Link β-catenin Calcium measurement Activation 19996314
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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