βIII-spectrin / TRP channels
Name: Spectrin beta chain, brain 2
(βIII-spectrin)
Official Symbol: SPTBN2
provided by HGNC
Function:
Probably plays an important role in neuronal membrane skeleton.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
![]() |
6712 |
O15020 |
DIP-47270N |
O15020 |
112590 |
O15020 |
hsa:6712 |
604985 |
||
| Mouse | ||||||||||
Rat
![]() |
29211 |
Q9QWN8 |
247889 |
Q9QWN8 |
rno:29211 |
|||||
PPI pairs:
Biological Process:
- GO:0051693
: actin filament capping - GO:0007411
: axon guidance - GO:0008219
: cell death - GO:0016192
: vesicle-mediated transport
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:604985
:
Spinocerebellar ataxia 5
(OMIM:600224
)
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
Screening
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPC5 |
|
βIII-spectrin | Affinity purification-mass spectrometry | Endogenous protein | Rat | Brain | Cerebral cortex lysates | 16025302 | ||
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)






Screening