AQP-2 / TRP channels

Name: Aquaporin-2 (AQP-2)
Official Symbol: AQP2 provided by HGNC
Function:
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).
Species External DB Questionmark
Entrez Gene UniprotKB DIP IntAct MINT BioGRID STRING IUPHAR-DB KEGG OMIM
Human
Seq		 359External P41181External     MINT-7890724External 106855External P41181External   hsa:359External 107777External
Mouse
Seq		 11827External P56402External DIP-58509NExternal   MINT-7890581External 198171External P56402External   mmu:11827External  
Rat
Seq		 25386External P34080External DIP-46223NExternal     247424External P34080External   rno:25386External  
PPI pairs:
Biological Process:
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Screening Toggle
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPC3 Link AQP-2 Inference Prediction 17699554
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Validation: In vivo validation Toggle
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPC3 Link AQP-2 Co-immunofluorescence staining Rat kidney duct section 17699554
TRPC3 Link AQP-2 Co-immunofluorescence staining Rat kidney medullary collecting duct 20107112
TRPC3 Link AQP-2 Co-immunoprecipitation mIMCD-3 17699554
TRPC3 Link AQP-2 Co-immunoprecipitation Rat medulla lysates 17699554
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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