Caspase-4/Caspase-11 / TRP channels
Name: Caspase-4
(Caspase-4/Caspase-11)
Official Symbol: CASP4
provided by HGNC
Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. Involved in ER-stress induced apoptosis. Cleaves caspase-1. {ECO:0000269|PubMed:15123740, ECO:0000269|Ref.14}.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species |
External DB
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Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
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837![]() |
P49662![]() |
DIP-44806N![]() |
P49662![]() |
MINT-1533864![]() |
107287![]() |
P49662![]() |
hsa:837![]() |
602664![]() |
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Mouse
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12363![]() |
P70343![]() |
mmu:12363![]() |
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Rat
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E9PSM0![]() |
Biological Process:
- GO:0006915
: apoptotic process
- GO:0097194
: execution phase of apoptosis
- GO:0006508
: proteolysis
- GO:0042981
: regulation of apoptotic process
- GO:0050727
: regulation of inflammatory response
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
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Screening
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Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPC1 |
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Caspase-4/Caspase-11 | Yeast two-hybrid | Not specified | Not specified | 24630989 | ||||
TRPC2 |
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Caspase-4/Caspase-11 | Speculation | Prediction | 24630989 |
(
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click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Validation: In vitro validation
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Assay with recombinant proteins | Reference | |||||||||
TRP channel construct | Interactor construct | |||||||||
TRP channel | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system | ||
TRPC1 |
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Caspase-4/Caspase-11 | Fusion protein-pull down assay | Not specified | Full-length | In vitro translation | Not specified | p30 domain | E. coli | 24630989 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Validation: In vivo validation
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Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
TRPC1 |
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Caspase-4/Caspase-11 | Co-immunoprecipitation | HEK293T | Not specified | Full-length | Not specified | Full-length | 24630989 | |
TRPC2 |
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Caspase-4/Caspase-11 | Co-immunoprecipitation | HEK293T | Not specified | Full-length | Not specified | Full-length | 24630989 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Characterization
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Binding region mapping | Stoichiometry | Affinity (Kd) | Reference | |||||||
TRP channel | Interactor | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
TRPC1 |
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Caspase-4/Caspase-11 | Co-immunoprecipitation | Not specified | 1-318 | Not specified | p30 domain | 24630989 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
