EFHC1 / TRP channels

Name: EF-hand domain-containing protein 1 (EFHC1)
Official Symbol: EFHC1 provided by HGNC
Function:
May enhance calcium influx through CACNA1E and stimulate programmed cell death.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).
Species External DB Questionmark
Entrez Gene UniprotKB DIP IntAct MINT BioGRID STRING IUPHAR-DB KEGG OMIM
Human
Seq		 114327External Q5JVL4External   Q5JVL4External MINT-1484267External 125313External Q5JVL4External   hsa:114327External 608815External
Mouse
Seq		 71877External Q9D9T8External       215000External Q9D9T8External   mmu:71877External  
Rat 301295External         256914External     rno:301295External  
PPI pairs:
Biological Process: No information in Gene Ontology
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Screening Toggle
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPM2 Link EFHC1 Inference Prediction 22226147
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Validation: In vivo validation Toggle
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPM2 Link EFHC1 Co-immunofluorescence staining HEK293 Human Full-length Mouse 319-1376 22226147
TRPM2 Link EFHC1 Co-immunoprecipitation Mouse brain microsome extracts 22226147
TRPM2 Link EFHC1 Co-immunoprecipitation HEK293 Human Full-length Mouse 319-1376 22226147
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Characterization Toggle
  Binding region mapping Stoichiometry Affinity (Kd) Reference
TRP channel Interactor
TRP channel Interactor Method Species Region Species Region
TRPM2 Link EFHC1 Co-immunoprecipitation Human 1-2214 Mouse Not determined 22226147
TRPM2 Link EFHC1 Co-immunoprecipitation Human 3169-4509 Mouse Not determined 22226147
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Functional consequence Toggle
TRP channel Interactor Method Post-translational modification Subcellular trafficking Activity Reference
TRPM2 Link EFHC1 Patch clamp Activation 22226147
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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