HSC70 / TRP channels

Name: Heat shock cognate 71 kDa protein (HSC70)
Official Symbol: HSPA8 provided by HGNC
Function:
Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co-chaperones.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).
Species External DB Questionmark
Entrez Gene UniprotKB DIP IntAct MINT BioGRID STRING IUPHAR-DB KEGG OMIM
Human
Seq		 3312External P11142External DIP-32874NExternal P11142External MINT-4998609External 109544External P11142External   hsa:3312External 600816External
Mouse
Seq		 15481External P63017External DIP-32353NExternal P63017External MINT-189032External 200428External P63017External   mmu:15481External  
Rat
Seq		 24468External P63018External DIP-33262NExternal P63018External MINT-2514077External 246629External P63018External   rno:24468External  
PPI pairs:
Biological Process:
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Screening Toggle
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPML1 Link HSC70 Yeast two-hybrid Human 94-298 Human Brain cDNA library 19117012
TRPML2 Link HSC70 Inference Prediction 19117012
TRPML3 Link HSC70 Inference Prediction 19117012
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Validation: In vitro validation Toggle
  Assay with recombinant proteins Reference
TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Expression system Species Region Expression system
TRPML1 Link HSC70 Fusion protein-pull down assay Human 94-298 In vitro translation Human Full-length In vitro translation 19117012
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Validation: In vivo validation Toggle
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPML1 Link HSC70 Co-immunoprecipitation CHO Human Full-length Human Full-length 19117012
TRPML1 Link HSC70 Co-immunoprecipitation CHO Human Full-length Not used 19117012
TRPML2 Link HSC70 Co-immunoprecipitation CHO Human Full-length Not used 19117012
TRPML3 Link HSC70 Co-immunoprecipitation CHO Human Full-length Not used 19117012
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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