NKAα1 / TRP channels

Name: Sodium/potassium-transporting ATPase subunit alpha-1 (NKAα1)
Official Symbol: ATP1A1 provided by HGNC
Function:
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).
Species External DB Questionmark
Entrez Gene UniprotKB DIP IntAct MINT BioGRID STRING IUPHAR-DB KEGG OMIM
Human
Seq
476External P05023External DIP-38196NExternal P05023External MINT-4998863External 106966External P05023External   hsa:476External 182310External
Mouse
Seq
11928External Q8VDN2External DIP-31885NExternal Q8VDN2External MINT-1797662External 198243External Q8VDN2External   mmu:11928External  
Rat
Seq
24211External P06685External DIP-37228NExternal P06685External MINT-3089277External 246399External P06685External   rno:24211External  
PPI pairs:
Biological Process:
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
Screening Toggle
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPC3 Link NKAα1 Affinity purification-mass spectrometry Not used as a bait Rat Brain Crude membranes 18205297
TRPC3 Link NKAα1 Inference Prediction 17012351
TRPC5 Link NKAα1 Affinity purification-mass spectrometry Endogenous protein Rat Brain Cerebral cortex lysates 16025302
TRPC6 Link NKAα1 Speculation Prediction 16025302
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Validation: In vivo validation Toggle
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPC3 Link NKAα1 Co-immunofluorescence staining Rat myocyte section 17012351
TRPC3 Link NKAα1 Co-immunoprecipitation Rat ventricle lysates 17012351
TRPC3 Link NKAα1 Co-immunoprecipitation Rat brain lysates 18205297
TRPC5 Link NKAα1 Co-immunoprecipitation Rat brain lysates 16025302
TRPC6 Link NKAα1 Co-immunofluorescence staining HEK293 Human Full-length Not used 16025302
TRPC6 Link NKAα1 Co-immunoprecipitation Rat kidney lysates 16025302
TRPC6 Link NKAα1 Co-immunoprecipitation Rat brain lysates 16025302
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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