Orai1 / TRP channels

Name: Calcium release-activated calcium channel protein 1 (Orai1)
Official Symbol: ORAI1 provided by HGNC
Function:
Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).
Species External DB Questionmark
Entrez Gene UniprotKB DIP IntAct MINT BioGRID STRING IUPHAR-DB KEGG OMIM
Human
Seq
84876External Q96D31External DIP-46289NExternal Q96D31External MINT-6780078External 124321External Q96D31External   hsa:84876External 610277External
Mouse
Seq
109305External Q8BWG9External       224640External Q8BWG9External   mmu:109305External  
Rat
Seq
304496External Q5M848External       257881External Q5M848External   rno:304496External  
PPI pairs:
Biological Process:
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
Screening Toggle
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPA1 Link Orai1 Inference Prediction 23994313
TRPC1 Link Orai1 Inference Prediction 18326500
TRPC3 Link Orai1 Inference Prediction 17360584
TRPC6 Link Orai1 Inference Prediction 17360584
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Validation: In vitro validation Toggle
  Assay with recombinant proteins Reference
TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Expression system Species Region Expression system
TRPC3 Link Orai1 Fusion protein-pull down assay Human 1-340 In vitro translation Human Full-length E. coli 17360584
TRPC3 Link Orai1 Fusion protein-pull down assay Human 676-848 In vitro translation Human Full-length E. coli 17360584
TRPC6 Link Orai1 Fusion protein-pull down assay Mouse 1-396 In vitro translation Human Full-length E. coli 17360584
TRPC6 Link Orai1 Fusion protein-pull down assay Mouse 732-930 In vitro translation Human Full-length E. coli 17360584
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Validation: In vivo validation Toggle
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPA1 Link Orai1 Co-immunoprecipitation MEG-01 23994313
TRPC1 Link Orai1 Co-immunoprecipitation Human platelets 18644792
TRPC1 Link Orai1 Co-immunoprecipitation Human atrial myocyte 23686296
TRPC1 Link Orai1 Co-immunoprecipitation Human parathyroid tissue 20194530
TRPC1 Link Orai1 Co-immunoprecipitation HEK293 18326500
TRPC3 Link Orai1 Co-immunoprecipitation COS-7 Human Full-length Human Full-length 17360584
TRPC3 Link Orai1 Co-immunoprecipitation HEK293 20022948
TRPC6 Link Orai1 Co-immunoprecipitation HEK293 Mouse Full-length Human Full-length 17360584
TRPC6 Link Orai1 Co-immunoprecipitation Human platelets 19260825
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Functional consequence Toggle
TRP channel Interactor Method Post-translational modification Subcellular trafficking Activity Reference
TRPC3 Link Orai1 Patch clamp Activation 18287061
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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