PIGEA-14/CBY1 / TRP channels

Name: Protein chibby homolog 1 (PIGEA-14/CBY1)
Official Symbol: CBY1 provided by HGNC
Function:
Inhibits the Wnt/Wingless pathway by binding to beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).
Species External DB Questionmark
Entrez Gene UniprotKB DIP IntAct MINT BioGRID STRING IUPHAR-DB KEGG OMIM
Human
Seq		 25776External Q9Y3M2External DIP-29651NExternal Q9Y3M2External MINT-2871551External 117311External Q9Y3M2External   hsa:25776External 607757External
Mouse
Seq		 73739External Q9D1C2External       216224External Q9D1C2External   mmu:73739External  
Rat
Seq		 246768External Q8K4I6External       251617External Q8K4I6External   rno:246768External  
PPI pairs:
Biological Process:
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Screening Toggle
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPP1 Link PIGEA-14/CBY1 Yeast two-hybrid Human 680-968 Human Kidney cDNA library 15194699
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Validation: In vivo validation Toggle
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPP1 Link PIGEA-14/CBY1 Co-immunofluorescence staining HeLa Human Full-length Human Full-length 15194699
TRPP1 Link PIGEA-14/CBY1 Co-immunoprecipitation LLC-PK1 Human Full-length Human Full-length 15194699
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Characterization Toggle
  Binding region mapping Stoichiometry Affinity (Kd) Reference
TRP channel Interactor
TRP channel Interactor Method Species Region Species Region
TRPP1 Link PIGEA-14/CBY1 Yeast two-hybrid Human 680-968 Human 60-112 15194699
TRPP1 Link PIGEA-14/CBY1 Yeast two-hybrid Human 833-923 Human Not determined 15194699
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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