PKARIIα / TRP channels

Name: cAMP-dependent protein kinase type II-alpha regulatory subunit (PKARIIα)
Official Symbol: PRKAR2A provided by HGNC
Function:
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).
Species External DB Questionmark
Entrez Gene UniprotKB DIP IntAct MINT BioGRID STRING IUPHAR-DB KEGG OMIM
Human
Seq
5576External P13861External DIP-552NExternal P13861External MINT-5000495External 111562External P13861External   hsa:5576External 176910External
Mouse
Seq
19087External P12367External DIP-32451NExternal P12367External MINT-1733887External 202368External P12367External   mmu:19087External  
Rat
Seq
29699External P12368External DIP-555NExternal P12368External MINT-4564663External 248317External P12368External   rno:29699External  
PPI pairs:
Biological Process:
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
Screening Toggle
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPV1 Link PKARIIα Inference Prediction 18463244
TRPV2 Link PKARIIα Inference Prediction 15249591
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Validation: In vivo validation Toggle
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPV1 Link PKARIIα Co-immunoprecipitation Mouse spinalcord tissue 18463244
TRPV2 Link PKARIIα Co-immunoprecipitation RBL-2H3 15249591
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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