PKD1L3/Polycystin-1L3 / TRP channels

Name: Polycystic kidney disease protein 1-like 3 (PKD1L3/Polycystin-1L3)
Official Symbol: PKD1L3 provided by HGNC
Function:
May function as an ion-channel regulator. May function with PKD2L1 as heteromeric taste channels (By similarity).
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).
Species External DB Questionmark
Entrez Gene UniprotKB DIP IntAct MINT BioGRID STRING IUPHAR-DB KEGG OMIM
Human
Seq		 342372External Q7Z443External DIP-50892NExternal Q7Z443External MINT-6743423External 131173External Q7Z443External   hsa:342372External 607895External
Mouse
Seq		 244646External Q2EG98External       232669External Q2EG98External   mmu:244646External  
Rat 365001External         265079External        
PPI pairs:
Biological Process:
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Screening Toggle
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPP2 Link PKD1L3/Polycystin-1L3 Inference Prediction 16891422
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Validation: In vivo validation Toggle
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPP2 Link PKD1L3/Polycystin-1L3 Co-immunofluorescence staining Mouse taste cell 16891422
TRPP2 Link PKD1L3/Polycystin-1L3 Co-immunoprecipitation HEK293T Mouse Full-length Mouse Full-length 16891422
TRPP2 Link PKD1L3/Polycystin-1L3 Co-immunoprecipitation HEK293T Mouse Full-length Mouse Full-length 20538909
TRPP2 Link PKD1L3/Polycystin-1L3 Co-immunoprecipitation Xenopus oocyte Human Full-length Human Full-length 23212381
TRPP2 Link PKD1L3/Polycystin-1L3 Co-immunoprecipitation HEK293T Mouse Full-length Mouse Full-length 18535624
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Characterization Toggle
  Binding region mapping Stoichiometry Affinity (Kd) Reference
TRP channel Interactor
TRP channel Interactor Method Species Region Species Region
TRPP2 Link PKD1L3/Polycystin-1L3 Co-immunoprecipitation Mouse Full-length Mouse 1594-2151 16891422
TRPP2 Link PKD1L3/Polycystin-1L3 Co-immunoprecipitation Mouse Not determined Mouse 1896-2040 20538909
TRPP2 Link PKD1L3/Polycystin-1L3 Single-molecule photobleaching 3:1 23212381
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Functional consequence Toggle
TRP channel Interactor Method Post-translational modification Subcellular trafficking Activity Reference
TRPP2 Link PKD1L3/Polycystin-1L3 Co-immunofluorescence staining Increase in plasma membrane level 20538909
TRPP2 Link PKD1L3/Polycystin-1L3 Patch clamp New channel creation 23212381
TRPP2 Link PKD1L3/Polycystin-1L3 Patch clamp New channel creation 18535624
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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