PLCƢ1 / TRP channels
Name:
PLCƢ1
*
UniProtKB IDs are not shown, 1) if protein (or gene) isotypes are not specified in the referred articles, 2) if their IDs are not found in the UniprotKB database or by us
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External DB
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| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
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| Mouse | ||||||||||
| Rat | ||||||||||
Biological Process:
No information in Gene Ontology
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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top
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Screening
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| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPC1 |
|
PLCƣ1 | Inference | Prediction | 15654973 | |||||
| TRPC2 |
|
PLCƣ1 | Inference | Prediction | 15329338 | |||||
| TRPC3 |
|
PLCƢ1 | Inference | Prediction | 11524429 | |||||
| TRPC3 |
|
PLCƣ1 | Inference | Prediction | 12437926 | |||||
| TRPC4 |
|
PLCƣ1 | Inference | Prediction | 12437926 | |||||
| TRPC4 |
|
PLCƢ1 | Inference | Prediction | 10980202 | |||||
| TRPC6 |
|
PLCƣ1 | Inference | Prediction | 19074769 | |||||
| TRPM6 |
|
PLCƢ1 | Inference | Prediction | 22180838 | |||||
| TRPM7 |
|
PLCƣ1 | Inference | Prediction | 11941371 | |||||
| TRPM7 |
|
PLCƢ1 | Yeast two-hybrid | Not used as a bait | Rat | Brain | cDNA library | 11161216 | ||
| TRPV1 |
|
PLCƣ1 | Inference | Prediction | 15744307 | |||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Validation: In vitro validation
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Assay with recombinant proteins | Reference | |||||||||
| TRP channel construct | Interactor construct | |||||||||
| TRP channel | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system | ||
| TRPC3 |
|
PLCƣ1 | Yeast two-hybrid | Human | 1-340 | Yeast | Rat | 750-1290 | Yeast | 12437926 |
| TRPC3 |
|
PLCƣ1 | Yeast two-hybrid | Human | 1-171 | Yeast | Rat | 796-920 | Yeast | 15744307 |
| TRPC4 |
|
PLCƣ1 | Yeast two-hybrid | Human | 1-330 | Yeast | Rat | 750-1290 | Yeast | 12437926 |
| TRPM6 |
|
PLCƢ1 | Fusion protein-pull down assay | Not specified | Kinase domain | E. coli | Not specified | Full-length | HEK293 lysates | 22180838 |
| TRPM7 |
|
PLCƢ1 | Fusion protein-pull down assay | Rat | 1352-1862 | E. coli | Rat | Full-length | HEK293T lysates | 11941371 |
| TRPM7 |
|
PLCƢ1 | Fusion protein-pull down assay | Not specified | Kinase domain | E. coli | Not specified | Full-length | HEK293 lysates | 22180838 |
| TRPM7 |
|
PLCƢ1 | Yeast two-hybrid | Rat | 1532-1862 | Yeast | Rat | 643-1216 | Yeast | 11941371 |
| TRPV1 |
|
PLCƣ1 | Yeast two-hybrid | Rat | 761-835 | Yeast | Rat | 796-920 | Yeast | 15744307 |
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Validation: In vivo validation
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
| Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
| TRPC1 |
|
PLCƣ1 | Co-immunofluorescence staining | Human keratinocyte | 15654973 | |||||
| TRPC1 |
|
PLCƣ1 | Co-immunoprecipitation | Human keratinocyte | 15654973 | |||||
| TRPC2 |
|
PLCƣ1 | Co-immunoprecipitation | CHO-S | Mouse | Full-length | Rat | Full-length | 15329338 | |
| TRPC2 |
|
PLCƣ1 | Co-immunoprecipitation | Mouse erythroblasts | 15329338 | |||||
| TRPC2 |
|
PLCƣ1 | Co-immunoprecipitation | CHO-S | Mouse | Full-length | Rat | Full-length | 22088247 | |
| TRPC3 |
|
PLCƣ1 | Co-immunoprecipitation | HEK293 | Mouse | Full-length | Human | Full-length | 19289841 | |
| TRPC3 |
|
PLCƢ1 | Co-immunoprecipitation | HEK293 | Human | Full-length | Not used | 11524429 | ||
| TRPC3 |
|
PLCƣ1 | Co-immunoprecipitation | HEK293T | Human | Full-length | Rat | Full-length | 21757714 | |
| TRPC3 |
|
PLCƣ1 | Co-immunoprecipitation | Human erythroid cell | 18276585 | |||||
| TRPC3 |
|
PLCƣ1 | Co-immunoprecipitation | HEK293T | Human | Full-length | Rat | Full-length | 18276585 | |
| TRPC3 |
|
PLCƣ1 | Co-immunoprecipitation | HEK293T | Human | Full-length | Rat | Full-length | 12437926 | |
| TRPC3 |
|
PLCƢ1 | Co-immunoprecipitation | MDCK | Not specified | Full-length | Not used | 15623527 | ||
| TRPC3 |
|
PLCƣ1 | Co-immunoprecipitation | HEK293T | Human | Full-length | Rat | Full-length | 19074769 | |
| TRPC4 |
|
PLCƢ1 | Co-immunofluorescence staining | Neonatal rat ventricular myocytes | Not used | Mouse | Full-length | 25049082 | ||
| TRPC4 |
|
PLCƢ1 | Co-immunoprecipitation | Neonatal rat ventricular myocytes | Human | Full-length | Mouse | Full-length | 25049082 | |
| TRPC4 |
|
PLCƢ1 | Co-immunoprecipitation | HEK293 | Mouse | Full-length | Not used | 10980202 | ||
| TRPC4 |
|
PLCƢ1 | Co-immunoprecipitation | Mouse brain tissue | 10980202 | |||||
| TRPC6 |
|
PLCƣ1 | Co-immunoprecipitation | HEK293T | Human | Full-length | Rat | Full-length | 19074769 | |
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Characterization
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Binding region mapping | Stoichiometry | Affinity (Kd) | Reference | |||||||
| TRP channel | Interactor | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
| TRPC3 |
|
PLCƣ1 | Fusion protein-pull down assay | Human | 1-52 | Rat | 794-933 | 16500902 | ||
| TRPC3 |
|
PLCƣ1 | Fusion protein-pull down assay | Human | 40-48 | Rat | 861-920 | 15744307 | ||
| TRPC3 |
|
PLCƣ1 | Yeast two-hybrid | Human | 1-340 | Rat | 780-920 | 12437926 | ||
| TRPC3 |
|
PLCƣ1 | Yeast two-hybrid | Human | 40-46 | Rat | 861-920 | 15744307 | ||
| TRPC4 |
|
PLCƣ1 | Yeast two-hybrid | Human | 1-330 | Rat | 780-920 | 12437926 | ||
| TRPM7 |
|
PLCƢ1 | Yeast two-hybrid | Rat | 1532-1862 | Rat | 643-797 | 11941371 | ||
| TRPV1 |
|
PLCƣ1 | Yeast two-hybrid | Rat | 761-835 | Rat | 861-920 | 15744307 | ||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Functional consequence
|
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TRP channel | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference | ||||||
| TRPC1 |
|
PLCƣ1 | Calcium measurement | Activation | 15654973 | |||||||
| TRPC3 |
|
PLCƣ1 | Calcium measurement | Activation | 12437926 | |||||||
| TRPC3 |
|
PLCƣ1 | Calcium measurement | Activation | 15744307 | |||||||
| TRPM7 |
|
PLCƢ1 | Patch clamp | Inhibition | 11941371 | |||||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)