RFP/TRIM27 / TRP channels
Name: Zinc finger protein RFP
(RFP/TRIM27)
Official Symbol: TRIM27
provided by HGNC
Function:
Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA (By similarity). E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
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|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
 |
5987 |
P14373 |
DIP-46665N |
P14373 |
MINT-1409274 |
111919 |
P14373 |
hsa:5987 |
602165 |
|
|
Mouse
|
19720 |
Q62158 |
DIP-49406N |
Q62158 |
MINT-1591463 |
202871 |
Q62158 |
mmu:19720 |
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| Rat | ||||||||||
PPI pairs:
Biological Process:
- GO:0008283
: cell proliferation - GO:0072643 : interferon-gamma secretion
- GO:0002820 : negative regulation of adaptive immune response
- GO:0090281 : negative regulation of calcium ion import
- GO:0045814 : negative regulation of gene expression, epigenetic
- GO:1900041 : negative regulation of interleukin-2 secretion
- GO:0006469 : negative regulation of protein kinase activity
- GO:0000122 : negative regulation of transcription from RNA polymerase II promoter
- GO:0032720 : negative regulation of tumor necrosis factor production
- GO:0070206 : protein trimerization
- GO:0007283 : spermatogenesis
- GO:0006351 : transcription, DNA-dependent
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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top
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Screening
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| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPML1 |
|
RFP/TRIM27 | Yeast two-hybrid | Human | Full-length | Human | Fetal brain | cDNA library | 16169070 | |
(:
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:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)