Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

• GO:0043297 : apical junction assembly
• GO:0007411 : axon guidance
• GO:0051301 : cell division
• GO:0044419 : interspecies interaction between organisms
• GO:0050771 : negative regulation of axonogenesis
• GO:0048011 : nerve growth factor receptor signaling pathway
• GO:0043931 : ossification involved in bone maturation
• GO:0048015 : phosphatidylinositol-mediated signaling
• GO:0030168 : platelet activation
• GO:0050772 : positive regulation of axonogenesis
• GO:0071777 : positive regulation of cell cycle cytokinesis
• GO:0043123 : positive regulation of I-kappaB kinase/NF-kappaB cascade
• GO:0045666 : positive regulation of neuron differentiation
• GO:0042346 : positive regulation of NF-kappaB import into nucleus
• GO:0051496 : positive regulation of stress fiber assembly
• GO:0030334 : regulation of cell migration
• GO:0033688 : regulation of osteoblast proliferation
• GO:0051056 : regulation of small GTPase mediated signal transduction
• GO:0007266 : Rho protein signal transduction
• GO:0090307 : spindle assembly involved in mitosis
• GO:0061383 : trabecula morphogenesis

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/