RyR2 / TRP channels

Name: Ryanodine receptor 2 (RyR2)
Official Symbol: RYR2 provided by HGNC
Function:
Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).
Species External DB Questionmark
Entrez Gene UniprotKB DIP IntAct MINT BioGRID STRING IUPHAR-DB KEGG OMIM
Human
Seq
6262External Q92736External DIP-38325NExternal Q92736External MINT-1201008External 112174External Q92736External   hsa:6262External 180902External
Mouse
Seq
20191External Q9ERN6External DIP-32244NExternal Q9ERN6External MINT-4129173External 203046External Q9ERN6External   mmu:20191External  
Rat
Seq
689560External B0LPN4External     UNK-5492549External 604379External B0LPN4External   rno:689560External  
PPI pairs:
Biological Process:
  • GO:0030509 External : BMP signaling pathway
  • GO:0060070 External : canonical Wnt receptor signaling pathway
  • GO:0060048 External : cardiac muscle contraction
  • GO:0003300 External : cardiac muscle hypertrophy
  • GO:0071313 External : cellular response to caffeine
  • GO:0005513 External : detection of calcium ion
  • GO:0003143 External : embryonic heart tube morphogenesis
  • GO:0008627 External : intrinsic apoptotic signaling pathway in response to osmotic stress
  • GO:0003220 External : left ventricular cardiac muscle tissue morphogenesis
  • GO:0010460 External : positive regulation of heart rate
  • GO:0086094 External : positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction
  • GO:0086029 External : Purkinje myocyte to ventricular cardiac muscle cell signaling
  • GO:0010881 External : regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
  • GO:0086005 External : regulation of ventricular cardiac muscle cell action potential
  • GO:0014808 External : release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
  • GO:0001666 External : response to hypoxia
  • GO:0051775 External : response to redox state
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
Screening Toggle
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPC3 Link RyR2 Inference Prediction 17012351
TRPP1 Link RyR2 Inference Prediction 17404231
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Validation: In vitro validation Toggle
  Assay with recombinant proteins Reference
TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Expression system Species Region Expression system
TRPP1 Link RyR2 Fusion protein-pull down assay Human 1-703 MDCK lysates Not used Mouse cardiac tissue microsome 17404231
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Validation: In vivo validation Toggle
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPC3 Link RyR2 Co-immunofluorescence staining Rat myocyte section 17012351
TRPC3 Link RyR2 Co-immunoprecipitation Rat ventricle lysates 17012351
TRPP1 Link RyR2 Co-immunoprecipitation Mouse heart tissue 17404231
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Characterization Toggle
  Binding region mapping Stoichiometry Affinity (Kd) Reference
TRP channel Interactor
TRP channel Interactor Method Species Region Species Region
TRPP1 Link RyR2 Fusion protein-pull down assay Human 703-968 Mouse Not determined 17404231
TRPP1 Link RyR2 Fusion protein-pull down assay Human 130-220 Mouse Not determined 17404231
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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