S100A10 / TRP channels

Name: Protein S100-A10 (S100A10)
Official Symbol: S100A10 provided by HGNC
Function:
Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).
Species External DB Questionmark
Entrez Gene UniprotKB DIP IntAct MINT BioGRID STRING IUPHAR-DB KEGG OMIM
Human
Seq		 6281External P60903External   P60903External MINT-1178035External 112189External P60903External   hsa:6281External 114085External
Mouse
Seq		 20194External P08207External DIP-49529NExternal P08207External MINT-4133605External 203049External P08207External   mmu:20194External  
Rat
Seq		 81778External P05943External DIP-46650NExternal P05943External MINT-4586198External 249650External P05943External   rno:81778External  
PPI pairs:
Biological Process:
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Screening Toggle
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPM3 Link S100A10 Inference Prediction 22451665
TRPV5 Link S100A10 Yeast two-hybrid Mouse C-terminus Mouse Kidney cDNA library 12660155
TRPV6 Link S100A10 Inference Prediction 12660155
TRPV6 Link S100A10 Yeast two-hybrid Human Not specified Human Not specified Not specified 16189514
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Validation: In vitro validation Toggle
  Assay with recombinant proteins Reference
TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Expression system Species Region Expression system
TRPM3 Link S100A10 Fluorescence probe labeling Human 35-124 E. coli Human Full-length E. coli 22451665
TRPM3 Link S100A10 Fluorescence probe labeling Human 291-382 E. coli Human Full-length E. coli 22451665
TRPV5 Link S100A10 Fusion protein-pull down assay Mouse Full-length E. coli Mouse Full-length Xenopus oocyte lysates 12660155
TRPV6 Link S100A10 Fusion protein-pull down assay Mouse Full-length E. coli Mouse Full-length Xenopus oocyte lysates 12660155
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Validation: In vivo validation Toggle
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPV5 Link S100A10 Co-immunofluorescence staining Rat duodenum tissue 12660155
TRPV6 Link S100A10 Co-immunofluorescence staining Rat duodenum tissue 12660155
TRPV6 Link S100A10 Co-immunoprecipitation Caco-2 cell 18187190
TRPV6 Link S100A10 Co-immunoprecipitation Human 16HBE14o- cell 18187190
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Characterization Toggle
  Binding region mapping Stoichiometry Affinity (Kd) Reference
TRP channel Interactor
TRP channel Interactor Method Species Region Species Region
TRPM3 Link S100A10 Fluorescence probe labeling Human 291-382 Human Not determined 22451665
TRPM3 Link S100A10 Fluorescence probe labeling Human 35-124 Human Not determined 22451665
TRPV5 Link S100A10 Fusion protein-pull down assay Mouse 591-595 Mouse Not determined 12660155
TRPV6 Link S100A10 Fusion protein-pull down assay Mouse 597-601 Mouse Not determined 12660155
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Functional consequence Toggle
TRP channel Interactor Method Post-translational modification Subcellular trafficking Activity Reference
TRPV5 Link S100A10 Co-immunofluorescence staining Increase in plasma membrane level 12660155
TRPV5 Link S100A10 Patch clamp Activation 12660155
TRPV6 Link S100A10 Co-immunofluorescence staining Increase in plasma membrane level 12660155
TRPV6 Link S100A10 Patch clamp Activation 12660155
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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