SNAP25 / TRP channels

Name: Synaptosomal-associated protein 25 (SNAP25)
Official Symbol: SNAP25 provided by HGNC
Function:
t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).
Species External DB Questionmark
Entrez Gene UniprotKB DIP IntAct MINT BioGRID STRING IUPHAR-DB KEGG OMIM
Human
Seq
6616External P60880External DIP-34554NExternal P60880External MINT-1403389External 112500External P60880External   hsa:6616External 600322External
Mouse
Seq
20614External P60879External DIP-29066NExternal
DIP-65NExternal
P60879External MINT-2411221External 203362External P60879External   mmu:20614External  
Rat
Seq
25012External P60881External DIP-29205NExternal
DIP-29593NExternal
P60881External MINT-95953External 247095External P60881External   rno:25012External  
PPI pairs:
Biological Process:
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
Screening Toggle
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPC1 Link SNAP25 Inference Prediction 15121806
TRPC3 Link SNAP25 Affinity purification-mass spectrometry Not used as a bait Rat Brain Crude membranes 18205297
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Validation: In vivo validation Toggle
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPC1 Link SNAP25 Co-immunoprecipitation Human platelets 15121806
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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