Synaptotagmin 1 / TRP channels
Name: Synaptotagmin-1
(Synaptotagmin 1)
Official Symbol: SYT1
provided by HGNC
Function:
May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species |
External DB
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Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
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6857![]() |
P21579![]() |
DIP-34042N![]() |
P21579![]() |
MINT-1400342![]() |
112723![]() |
P21579![]() |
hsa:6857![]() |
185605![]() |
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Mouse
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20979![]() |
P46096![]() |
DIP-31322N![]() |
P46096![]() |
MINT-4136555![]() |
203611![]() |
P46096![]() |
mmu:20979![]() |
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Rat
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25716![]() |
P21707![]() |
DIP-29064N![]() DIP-642N ![]() |
P21707![]() |
MINT-4542559![]() |
247745![]() |
P21707![]() |
rno:25716![]() |
Biological Process:
- GO:0005513
: detection of calcium ion
- GO:0014047
: glutamate secretion
- GO:0007269
: neurotransmitter secretion
- GO:0051260
: protein homooligomerization
- GO:0017158
: regulation of calcium ion-dependent exocytosis
- GO:0017157
: regulation of exocytosis
- GO:0016079
: synaptic vesicle exocytosis
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
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Screening
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Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPC3 |
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Synaptotagmin 1 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
TRPM7 |
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Synaptotagmin 1 | Inference | Prediction | 17088214 | |||||
TRPV1 |
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Synaptotagmin 1 | Inference | Prediction | 15066994 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Validation: In vitro validation
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Assay with recombinant proteins | Reference | |||||||||
TRP channel construct | Interactor construct | |||||||||
TRP channel | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system | ||
TRPV1 |
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Synaptotagmin 1 | Fusion protein-pull down assay | Rat | 1-414 | E. coli | Human | Full-length | In vitro translation | 15066994 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Validation: In vivo validation
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Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
TRPC3 |
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Synaptotagmin 1 | Co-immunoprecipitation | Rat brain lysates | 18205297 | |||||
TRPM7 |
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Synaptotagmin 1 | Co-immunoprecipitation | Rat brain synaptic vesicle | 17088214 | |||||
TRPV1 |
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Synaptotagmin 1 | Co-immunoprecipitation | HEK293 | Human | Full-length | Human | Full-length | 15066994 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
