TPC1 / TRP channels

Name: Two pore calcium channel protein 1 (TPC1)
Official Symbol: TPCN1 provided by HGNC
Function:
Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal and endosomal membrane.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).
Species External DB Questionmark
Entrez Gene UniprotKB DIP IntAct MINT BioGRID STRING IUPHAR-DB KEGG OMIM
Human
Seq		 53373External Q9ULQ1External   Q9ULQ1External   119760External Q9ULQ1External 392External hsa:53373External 609666External
Mouse
Seq		 252972External Q9EQJ0External       232984External Q9EQJ0External   mmu:252972External  
Rat
Seq		 246215External Q9WTN5External       251532External Q9WTN5External   rno:246215External  
PPI pairs:
Biological Process: No information in Gene Ontology
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Screening Toggle
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPML1 Link TPC1 Inference Prediction 21540176
TRPML3 Link TPC1 Inference Prediction 21540176
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Validation: In vivo validation Toggle
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPML1 Link TPC1 Co-immunofluorescence staining HEK293T Human Full-length Human Full-length 21540176
TRPML1 Link TPC1 Co-immunofluorescence staining HeLa Human Full-length Human Full-length 21540176
TRPML1 Link TPC1 Co-immunofluorescence staining SK-BR-3 Human Full-length Human Full-length 21540176
TRPML1 Link TPC1 Co-immunoprecipitation HEK293T Human Full-length Human Full-length 21540176
TRPML3 Link TPC1 Co-immunofluorescence staining HEK293T Human Full-length Human Full-length 21540176
TRPML3 Link TPC1 Co-immunofluorescence staining HeLa Human Full-length Human Full-length 21540176
TRPML3 Link TPC1 Co-immunofluorescence staining SK-BR-3 Human Full-length Human Full-length 21540176
TRPML3 Link TPC1 Co-immunoprecipitation HEK293T Human Full-length Human Full-length 21540176
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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