TRPA1 / interactors

Name: Transient receptor potential cation channel subfamily A member 1 (TRPA1)
Official Symbol: TRPA1 provided by HGNC
Function:
Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity).
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).
Species External DB Questionmark
Entrez Gene UniprotKB DIP IntAct MINT BioGRID STRING IUPHAR-DB KEGG OMIM
Human
Seq		 8989External O75762External       114471External O75762External 485External hsa:8989External 604775External
Mouse
Seq		 277328External Q8BLA8External       234929External Q8BLA8External   mmu:277328External  
Rat
Seq		 312896External Q6RI86External       260269External Q6RI86External   rno:312896External  
Biological Process: No information in Gene Ontology
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Screening Toggle
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPA1 Link AKAP-5 Speculation Prediction 18701070
TRPA1 Link CYLD Inference Prediction 16500080
TRPA1 Link Secretogranin3 Yeast two-hybrid Rat N-terminus Rat Brain cDNA library 18802106
TRPA1 Link TRPV1 Inference Prediction 20231274
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Validation: In vivo validation Toggle
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPA1 Link AKAP-5 Co-immunoprecipitation HEK293 Mouse Full-length Not used 18701070
TRPA1 Link CYLD Co-immunoprecipitation HEK293 Human Full-length Human Full-length 16500080
TRPA1 Link CYLD Co-immunoprecipitation MDA-MB-435 Not used Human Full-length 16500080
TRPA1 Link CYLD Co-immunoprecipitation Human Jurkat T cell 16500080
TRPA1 Link Secretogranin3 Co-immunoprecipitation RBL-2H3 18802106
TRPA1 Link TRPV1 Co-immunoprecipitation CHO Mouse Full-length Rat Full-length 20231274
TRPA1 Link TRPV1 Co-immunoprecipitation Mouse trigeminal ganglia lysates 20231274
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Functional consequence Toggle
TRP channel Interactor Method Post-translational modification Subcellular trafficking Activity Reference
TRPA1 Link CYLD In vivo PTM assay De-ubiquitination 16500080
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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