TRPC1 / interactors

Name: Short transient receptor potential channel 1 (TRPC1)
Official Symbol: TRPC1 provided by HGNC
Function:
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).
Species External DB Questionmark
Entrez Gene UniprotKB DIP IntAct MINT BioGRID STRING IUPHAR-DB KEGG OMIM
Human
Seq		 7220External P48995External DIP-35698NExternal P48995External   113071External P48995External 486External hsa:7220External 602343External
Mouse
Seq		 22063External Q61056External DIP-33928NExternal Q61056External   204327External Q61056External   mmu:22063External  
Rat
Seq		 89821External Q9QX01External       250144External Q9QX01External   rno:89821External  
Biological Process:
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Screening Toggle
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPC1 Link BKca Inference Prediction 19168436
TRPC1 Link BMPR-2 Affinity purification-mass spectrometry Not used as a bait Mouse Leg muscle C2C12 lysates 15188402
TRPC1 Link Calcineurin Inference Prediction 23228564
TRPC1 Link Calmodulin Inference Prediction 11983166
TRPC1 Link Cav1.2 Inference Prediction 21672930
TRPC1 Link Caveolin-1 Inference Prediction 10766822
TRPC1 Link Caveolin-3 Inference Prediction 18544631
TRPC1 Link Cortactin Inference Prediction 19351713
TRPC1 Link D2R Yeast two-hybrid Not used as a bait Human Fetal brain cDNA library 18261457
TRPC1 Link Dystrophin Inference Prediction 17202249
TRPC1 Link Enkurin Inference Prediction 15385169
TRPC1 Link FGFR-1 Inference Prediction 15758179
TRPC1 Link FKBP52/FKBP4 Inference Prediction 15199065
TRPC1 Link Gαq/11 Inference Prediction 10766822
TRPC1 Link Homer-1 Inference Prediction 14505576
TRPC1 Link Homer-2 Inference Prediction 14505576
TRPC1 Link Homer-3 Inference Prediction 14505576
TRPC1 Link I-MFA Yeast two-hybrid Human 639-750 Mouse Embryonic cDNA library 14530267
TRPC1 Link I-MFA Yeast two-hybrid Human 639-750 Human Fetal kidney cDNA library 14530267
TRPC1 Link IP3R2 Inference Prediction 10970773
TRPC1 Link IP3R3 Inference Prediction 10766822
TRPC1 Link MGLUR1 Inference Prediction 14614461
TRPC1 Link MxA Inference Prediction 15757897
TRPC1 Link NCS-1 Inference Prediction 18261457
TRPC1 Link Orai1 Inference Prediction 18326500
TRPC1 Link Orai2 Speculation Prediction 22640869
TRPC1 Link Orai3 Speculation Prediction 22640869
TRPC1 Link PLCγ1 Inference Prediction 15654973
TRPC1 Link PMCA Speculation Prediction 11983166
TRPC1 Link Protein 4.1 Inference Prediction 22534489
TRPC1 Link RhoA Inference Prediction 12766172
TRPC1 Link RNF24 Inference Prediction 17850865
TRPC1 Link RyR1 Affinity purification-mass spectrometry Not used as a bait Rabbit Fast-twitch muscle Triad vesicles 18215135
TRPC1 Link SERCA2 Inference Prediction 18068335
TRPC1 Link SERCA3 Inference Prediction 18068335
TRPC1 Link SNAP25 Inference Prediction 15121806
TRPC1 Link SRC Inference Prediction 16407161
TRPC1 Link STIM1 Inference Prediction 16906149
TRPC1 Link STIM2 Speculation Prediction 22640869
TRPC1 Link TRPC3 Inference Prediction 9215637
TRPC1 Link TRPC4 Inference Prediction 11301024
TRPC1 Link TRPC5 Inference Prediction 11301024
TRPC1 Link TRPC6 Inference Prediction 12857742
TRPC1 Link TRPC7 Inference Prediction 15972814
TRPC1 Link TRPP1 Inference Prediction 10097141
TRPC1 Link VAMP Inference Prediction 15121806
TRPC1 Link α-actinin-1 Inference Prediction 17892531
TRPC1 Link α1-syntrophin Inference Prediction 17202249
TRPC1 Link β-tubulin-5 Affinity purification-mass spectrometry Human Full-length Bovine Retinal Tissue lysates 15935109
TRPC1 Link β-tubulin-5 Yeast two-hybrid Human 1-139 Rat Brain cDNA library 15935109
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Validation: In vitro validation Toggle
  Assay with recombinant proteins Reference
TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Expression system Species Region Expression system
TRPC1 Link Calmodulin Fusion protein-pull down assay Human 649-793 E. coli Not specified Full-length Not specified 11983166
TRPC1 Link Calmodulin Fusion protein-pull down assay Human 1-341 In vitro translation Not specified Full-length E. coli 12601176
TRPC1 Link Caveolin-1 Fusion protein-pull down assay Human 1-347 E. coli Not specified Full-length HSG cell lysates 12732636
TRPC1 Link Caveolin-1 Yeast two-hybrid Not specified 317-347 Yeast Not specified Full-length Yeast 19897728
TRPC1 Link D2R Fusion protein-pull down assay Human 638-759 E. coli Human 131-151 E. coli 18261457
TRPC1 Link Enkurin Fusion protein-pull down assay Human Full-length HEK293 lysates Mouse Full-length HEK293 lysates 15385169
TRPC1 Link Enkurin Yeast two-hybrid Human N-terminus Yeast Mouse Full-length Yeast 15385169
TRPC1 Link FKBP52/FKBP4 Co-immunoprecipitation Human Full-length Sf9 lysates Human Full-length Sf9 lysates 15199065
TRPC1 Link FKBP52/FKBP4 Fusion protein-pull down assay Human 1-316 HEK293 lysates Human Full-length E. coli 19945390
TRPC1 Link Homer-3 Fusion protein-pull down assay Not used Rat cerebellum lysates Not specified Full-length E. coli 14505576
TRPC1 Link I-MFA Fusion protein-pull down assay Human 639-750 E. coli Human Full-length E. coli 14530267
TRPC1 Link NCS-1 Fusion protein-pull down assay Human 639-759 E. coli Human Full-length E. coli 18261457
TRPC1 Link RNF24 Fusion protein-pull down assay Not specified 3-200 In vitro translation Human 98-148 E. coli 17850865
TRPC1 Link SRC Fusion protein-pull down assay Mouse 1-341 In vitro translation Chicken Full-length E. coli 16407161
TRPC1 Link STIM1 Fusion protein-pull down assay Not specified 1-347 E. coli Not used HSG cell lysates 17224452
TRPC1 Link TRPC3 Fusion protein-pull down assay Not specified 1-347 E. coli Not specified Full-length HEK293 lysates 15834157
TRPC1 Link TRPC3 Yeast two-hybrid Not specified 1-347 Yeast Not specified 642-842 Yeast 15834157
TRPC1 Link TRPP1 Fusion protein-pull down assay Human 662-750 E. coli Human 680-968 In vitro translation 10097141
TRPC1 Link α1-syntrophin Fusion protein-pull down assay Not used C57BL/10 mouse muscle cell lysates Mouse 75-170 E. coli 19812031
TRPC1 Link α1-syntrophin Fusion protein-pull down assay Not used Mouse myotube lysates Not specified 75-170 E. coli 17202249
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Validation: In vivo validation Toggle
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPC1 Link BKca Co-immunofluorescence staining Rat aortic vascular smooth muscle cell 19168436
TRPC1 Link BKca Co-immunoprecipitation HEK293 Human Full-length Human Full-length 19168436
TRPC1 Link BKca Co-immunoprecipitation Rat vascular smooth muscle cell 19168436
TRPC1 Link Cav1.2 Co-immunoprecipitation Chick embryonic heart lysates 21672930
TRPC1 Link Caveolin-1 Co-immunofluorescence staining HUVEC Human Full-length Mouse Full-length 20705915
TRPC1 Link Caveolin-1 Co-immunofluorescence staining Rat caudal artery section 14551243
TRPC1 Link Caveolin-1 Co-immunofluorescence staining HSG cell Not used Not specified Full-length 12732636
TRPC1 Link Caveolin-1 Co-immunofluorescence staining HSG cell Human Full-length Not specified Full-length 12732636
TRPC1 Link Caveolin-1 Co-immunofluorescence staining MDCK Human Full-length Not specified Full-length 12732636
TRPC1 Link Caveolin-1 Co-immunofluorescence staining HSG cell 19897728
TRPC1 Link Caveolin-1 Co-immunoprecipitation C2C12 19351713
TRPC1 Link Caveolin-1 Co-immunoprecipitation Rat caudal artery cell 14551243
TRPC1 Link Caveolin-1 Co-immunoprecipitation HSG cell 18430726
TRPC1 Link Caveolin-1 Co-immunoprecipitation HSG cell Human Full-length Not used 10766822
TRPC1 Link Caveolin-1 Co-immunoprecipitation MDCK Human Full-length Not specified Full-length 12732636
TRPC1 Link Caveolin-1 Co-immunoprecipitation HSG cell 19897728
TRPC1 Link Caveolin-1 Co-immunoprecipitation HSG cell Human Full-length Not used 10980191
TRPC1 Link Caveolin-1 Fluorescence resonance energy transfer HSG cell Not specified Full-length Not specified Full-length 19897728
TRPC1 Link Caveolin-3 Co-immunofluorescence staining Mouse skeletal muscle section 18544631
TRPC1 Link Caveolin-3 Co-immunoprecipitation Mouse skeletal muscle cell 18544631
TRPC1 Link Caveolin-3 Fluorescence resonance energy transfer Mouse skeletal muscle Human Full-length Mouse Full-length 18544631
TRPC1 Link Cortactin Co-immunoprecipitation C2C12 19351713
TRPC1 Link D2R Co-immunofluorescence staining Monkey prefrontal cortex 18261457
TRPC1 Link D2R Co-immunoprecipitation Rat striatal tissue 18261457
TRPC1 Link D2R Co-immunoprecipitation Rat cortex tissue 18261457
TRPC1 Link Dystrophin Co-immunofluorescence staining SolC57 17202249
TRPC1 Link Dystrophin Co-immunoprecipitation Mouse hind limb muscle 17202249
TRPC1 Link Dystrophin Co-immunoprecipitation SolC57 17202249
TRPC1 Link FGFR-1 Co-immunofluorescence staining Rat neural stem cell 15758179
TRPC1 Link FGFR-1 Co-immunoprecipitation Rat telencephalon 15758179
TRPC1 Link FKBP52/FKBP4 Co-immunoprecipitation HEK293 Human Full-length Not used 19945390
TRPC1 Link FKBP52/FKBP4 Co-immunoprecipitation Rat cerebral cortex 15199065
TRPC1 Link FKBP52/FKBP4 Co-immunoprecipitation Human platelets 23228564
TRPC1 Link FKBP52/FKBP4 Co-immunoprecipitation MEG-01 23228564
TRPC1 Link Gαq/11 Co-immunoprecipitation HSG cell Human Full-length Not used 10766822
TRPC1 Link Homer Co-immunofluorescence staining Mouse skeletal muscle 18268005
TRPC1 Link Homer Co-immunoprecipitation Mouse skeletal muscle 18268005
TRPC1 Link Homer-1 Co-immunoprecipitation Human platelets 22506990
TRPC1 Link Homer-1 Co-immunoprecipitation HEK293 Human Full-length Not used 14505576
TRPC1 Link Homer-1 Co-immunoprecipitation Rat brain hippocampus 14505576
TRPC1 Link Homer-1 Co-immunoprecipitation Rat astrocyte 16905188
TRPC1 Link Homer-2 Co-immunoprecipitation HEK293 Human Full-length Not used 14505576
TRPC1 Link Homer-3 Co-immunoprecipitation HEK293 Human Full-length Not used 19945390
TRPC1 Link Homer-3 Co-immunoprecipitation HEK293 Human Full-length Not used 14505576
TRPC1 Link Homer-3 Co-immunoprecipitation Rat cerebellum lysates 14505576
TRPC1 Link I-MFA Co-immunoprecipitation HEK293T Human Full-length Human Full-length 14530267
TRPC1 Link I-MFA Co-immunoprecipitation Rat liver tissue 14530267
TRPC1 Link I-MFA Co-immunoprecipitation NALM-6 14530267
TRPC1 Link I-MFA Co-immunoprecipitation Rat kidney tissue 14530267
TRPC1 Link IP3R2 Co-immunoprecipitation Human platelets 17681754
TRPC1 Link IP3R2 Co-immunoprecipitation Human platelets 11336651
TRPC1 Link IP3R2 Co-immunoprecipitation Human platelets 18068335
TRPC1 Link IP3R2 Co-immunoprecipitation Human platelets 16870612
TRPC1 Link IP3R2 Co-immunoprecipitation Human platelets 18191041
TRPC1 Link IP3R2 Co-immunoprecipitation Rat astrocyte 16905188
TRPC1 Link IP3R2 Co-immunoprecipitation Human platelets 18249094
TRPC1 Link IP3R2 Co-immunoprecipitation Human platelets 15121806
TRPC1 Link IP3R2 Co-immunoprecipitation Human platelets 12196544
TRPC1 Link IP3R2 Co-immunoprecipitation Human platelets 23228564
TRPC1 Link IP3R2 Co-immunoprecipitation MEG-01 23228564
TRPC1 Link IP3R2 Co-immunoprecipitation Human platelets 10970773
TRPC1 Link IP3R3 Co-immunofluorescence staining Human keratinocyte 15654973
TRPC1 Link IP3R3 Co-immunoprecipitation Human keratinocyte 15654973
TRPC1 Link IP3R3 Co-immunoprecipitation HEK293 Human Full-length Not used 14505576
TRPC1 Link IP3R3 Co-immunoprecipitation HSG cell Human Full-length Not used 10766822
TRPC1 Link IP3R3 Co-immunoprecipitation HSG cell Human Full-length Not used 10980191
TRPC1 Link MGLUR1 Co-immunoprecipitation CHO Human Full-length Not specified Not specified 14614461
TRPC1 Link MGLUR1 Co-immunoprecipitation HEK293 Human Full-length Not specified Not specified 14614461
TRPC1 Link MGLUR1 Co-immunoprecipitation Rat cerebellum lysates 14614461
TRPC1 Link MxA Co-immunoprecipitation HEK293T Human Full-length Human Full-length 15757897
TRPC1 Link Orai1 Co-immunoprecipitation Human parathyroid tissue 20194530
TRPC1 Link Orai1 Co-immunoprecipitation HEK293 18326500
TRPC1 Link Orai1 Co-immunoprecipitation Human platelets 18644792
TRPC1 Link Orai2 Co-immunoprecipitation Human platelets 22640869
TRPC1 Link Orai3 Co-immunoprecipitation Human platelets 22640869
TRPC1 Link PLCγ1 Co-immunofluorescence staining Human keratinocyte 15654973
TRPC1 Link PLCγ1 Co-immunoprecipitation Human keratinocyte 15654973
TRPC1 Link PMCA Co-immunoprecipitation HSG cell Human Full-length Not used 11983166
TRPC1 Link Protein 4.1 Co-immunoprecipitation Rat pumonary aortic endothelial cell 22534489
TRPC1 Link RhoA Co-immunofluorescence staining Human pulmonary arterial endothelial cell Not used Not specified Full-length 12766172
TRPC1 Link RhoA Co-immunoprecipitation Human pulmonary arterial endothelial cell 12766172
TRPC1 Link RyR1 Co-immunoprecipitation Mouse skeletal myotube lysates 18215135
TRPC1 Link SERCA2 Co-immunoprecipitation Human platelets 18068335
TRPC1 Link SERCA2 Co-immunoprecipitation Human platelets 18191041
TRPC1 Link SERCA3 Co-immunoprecipitation Human platelets 18068335
TRPC1 Link SERCA3 Co-immunoprecipitation Human platelets 18191041
TRPC1 Link SNAP25 Co-immunoprecipitation Human platelets 15121806
TRPC1 Link STIM1 Co-immunofluorescence staining Human saphenous vein vascular smooth muscle cell 18802022
TRPC1 Link STIM1 Co-immunofluorescence staining HEK293 Human Full-length Human Full-length 16906149
TRPC1 Link STIM1 Co-immunofluorescence staining Mouse pulmonary arterial smooth muscle cell 23034388
TRPC1 Link STIM1 Co-immunofluorescence staining HSG cell Human Full-length Not specified Full-length 17224452
TRPC1 Link STIM1 Co-immunofluorescence staining HSG cell 19897728
TRPC1 Link STIM1 Co-immunoprecipitation HEK293T Rat Full-length Rat Full-length 22201561
TRPC1 Link STIM1 Co-immunoprecipitation Human saphenous vein vascular smooth muscle cell 18802022
TRPC1 Link STIM1 Co-immunoprecipitation Human saphenous vein vascular smooth muscle cell Human Full-length Not specified Full-length 18802022
TRPC1 Link STIM1 Co-immunoprecipitation Human platelets 17892531
TRPC1 Link STIM1 Co-immunoprecipitation Human parathyroid tissue 20194530
TRPC1 Link STIM1 Co-immunoprecipitation SH-SY5Y 22446186
TRPC1 Link STIM1 Co-immunoprecipitation HSG cell 20488539
TRPC1 Link STIM1 Co-immunoprecipitation Rat normal small intestine cell line IEC-6 22592407
TRPC1 Link STIM1 Co-immunoprecipitation Rat normal small intestine cell line IEC-6 (IEC-Cdx2L1 stable cell) 22592407
TRPC1 Link STIM1 Co-immunoprecipitation Caco-2 cell 22592407
TRPC1 Link STIM1 Co-immunoprecipitation HEK293 Human Full-length Not used 19228695
TRPC1 Link STIM1 Co-immunoprecipitation Human platelets 16870612
TRPC1 Link STIM1 Co-immunoprecipitation Mouse pulmonary arterial smooth muscle cell 19332490
TRPC1 Link STIM1 Co-immunoprecipitation Rat brain tissue 16906149
TRPC1 Link STIM1 Co-immunoprecipitation HEK293 Human Full-length Human Full-length 16906149
TRPC1 Link STIM1 Co-immunoprecipitation Mouse pulmonary arterial smooth muscle cell 23034388
TRPC1 Link STIM1 Co-immunoprecipitation Human platelets 18249094
TRPC1 Link STIM1 Co-immunoprecipitation HEK293 18326500
TRPC1 Link STIM1 Co-immunoprecipitation HSG cell 18430726
TRPC1 Link STIM1 Co-immunoprecipitation HEK293 Not used Not specified Full-length 17224452
TRPC1 Link STIM1 Co-immunoprecipitation A7r5 Not used Not specified Full-length 17224452
TRPC1 Link STIM1 Co-immunoprecipitation Human platelets 18644792
TRPC1 Link STIM1 Co-immunoprecipitation HSG cell 19897728
TRPC1 Link STIM2 Co-immunoprecipitation Human platelets 22640869
TRPC1 Link TRPC3 Co-immunoprecipitation Rat brain microsome 12857742
TRPC1 Link TRPC3 Co-immunoprecipitation HSY cell 15834157
TRPC1 Link TRPC3 Co-immunoprecipitation Human platelets 19260825
TRPC1 Link TRPC3 Co-immunoprecipitation HEK293 15972814
TRPC1 Link TRPC3 Co-immunoprecipitation Rat carotid artery smooth muscle cell 19502552
TRPC1 Link TRPC3 Co-immunoprecipitation Mouse skeletal myotube lysates 18215135
TRPC1 Link TRPC3 Co-immunoprecipitation HEK293T Human Full-length Human Full-length 9215637
TRPC1 Link TRPC3 Co-immunoprecipitation C2C12 21996795
TRPC1 Link TRPC3 Co-immunoprecipitation HEK293 Human Full-length Human Full-length 17486119
TRPC1 Link TRPC4 Co-immunofluorescence staining Human glomerular mesangial cell 16418302
TRPC1 Link TRPC4 Co-immunofluorescence staining BAE-1 16818374
TRPC1 Link TRPC4 Co-immunoprecipitation Human glomerular mesangial cell 16418302
TRPC1 Link TRPC4 Co-immunoprecipitation Mouse lung endothelial cell Mouse Full-length Mouse Full-length 22210847
TRPC1 Link TRPC4 Co-immunoprecipitation Rat brain microsome 12857742
TRPC1 Link TRPC4 Co-immunoprecipitation Human platelets 17892531
TRPC1 Link TRPC4 Co-immunoprecipitation Rat brain microsome 11301024
TRPC1 Link TRPC4 Co-immunoprecipitation BAE-1 16818374
TRPC1 Link TRPC4 Co-immunoprecipitation Human glomerular mesangial cell 19307462
TRPC1 Link TRPC4 Co-immunoprecipitation HEK293 Human Full-length Mouse Full-length 12032305
TRPC1 Link TRPC4 Co-immunoprecipitation C57BL/10 mouse muscle cell 19812031
TRPC1 Link TRPC4 Co-immunoprecipitation Sf9 Human Full-length Bovine Full-length 12377790
TRPC1 Link TRPC4 Co-immunoprecipitation Rat brain synaptome 12377790
TRPC1 Link TRPC4 Co-immunoprecipitation Human platelets 16270640
TRPC1 Link TRPC4 Co-immunoprecipitation Mouse lung endothelium cell 17416589
TRPC1 Link TRPC4 Fluorescence resonance energy transfer Rat pumonary aortic endothelial cell 22534489
TRPC1 Link TRPC4 Fluorescence resonance energy transfer HEK293 Human Full-length Mouse Full-length 12032305
TRPC1 Link TRPC5 Co-immunoprecipitation Rat brain microsome 12857742
TRPC1 Link TRPC5 Co-immunoprecipitation Rat brain microsome 11301024
TRPC1 Link TRPC5 Co-immunoprecipitation HEK293 Human Full-length Mouse Full-length 11301024
TRPC1 Link TRPC5 Co-immunoprecipitation Sf9 Human Full-length Mouse Full-length 12377790
TRPC1 Link TRPC5 Co-immunoprecipitation Rat brain synaptome 12377790
TRPC1 Link TRPC5 Co-immunoprecipitation Rabbit coronary artery 18356201
TRPC1 Link TRPC5 Co-immunoprecipitation Rabbit mesenteric artery 18356201
TRPC1 Link TRPC5 Co-immunoprecipitation Rabbit portal vein 18356201
TRPC1 Link TRPC5 Co-immunoprecipitation Human platelets 16270640
TRPC1 Link TRPC5 Co-immunoprecipitation Mouse vascular smooth muscle cell 21968068
TRPC1 Link TRPC5 Fluorescence resonance energy transfer HEK293 Human Full-length Mouse Full-length 12032305
TRPC1 Link TRPC6 Co-immunofluorescence staining Human glomerular mesangial cell 16418302
TRPC1 Link TRPC6 Co-immunoprecipitation Human glomerular mesangial cell 16418302
TRPC1 Link TRPC6 Co-immunoprecipitation Rat brain microsome 12857742
TRPC1 Link TRPC6 Co-immunoprecipitation Human platelets 18191041
TRPC1 Link TRPC7 Co-immunoprecipitation HEK293 15972814
TRPC1 Link TRPP1 Co-immunofluorescence staining HEK293 tsA 201 Human Full-length Human Full-length 19850920
TRPC1 Link TRPP1 Co-immunofluorescence staining mIMCD-3 18323855
TRPC1 Link TRPP1 Co-immunofluorescence staining HEK293T Human Full-length Human Full-length 10097141
TRPC1 Link TRPP1 Co-immunoprecipitation HEK293T Human Full-length Not specified Not specified 14530267
TRPC1 Link TRPP1 Co-immunoprecipitation Human glomerular mesangial cell Human Full-length Not used 18256307
TRPC1 Link TRPP1 Co-immunoprecipitation HEK293 Mouse Full-length Human Full-length 19812035
TRPC1 Link TRPP1 Co-immunoprecipitation HEK293 tsA 201 Human Full-length Human Full-length 19850920
TRPC1 Link TRPP1 Co-immunoprecipitation Rat kidney tissue 18323855
TRPC1 Link TRPP1 Co-immunoprecipitation HEK293 tsA 201 Human Full-length Human Full-length 20682256
TRPC1 Link TRPP1 Co-immunoprecipitation HEK293T Human Full-length Human Full-length 10097141
TRPC1 Link TRPV4 Co-immunofluorescence staining HEK293 Human Full-length Mouse Full-length 20093626
TRPC1 Link TRPV4 Co-immunofluorescence staining Rat mesenteric artery endothelial cell lysates 20093626
TRPC1 Link TRPV4 Co-immunoprecipitation HEK293 Human Full-length Mouse Full-length 20093626
TRPC1 Link TRPV4 Co-immunoprecipitation Rat mesenteric artery endothelial cell lysates 20093626
TRPC1 Link TRPV4 Fluorescence resonance energy transfer HEK293 Human Full-length Mouse Full-length 20093626
TRPC1 Link TRPV4 Fluorescence resonance energy transfer HEK293 Human Full-length Mouse Full-length 20705915
TRPC1 Link TRPV4 Fluorescence resonance energy transfer HEK293 Human Full-length Mouse Full-length 21871867
TRPC1 Link TRPV6 Co-immunoprecipitation HEK293 Human Full-length Rat Full-length 22932896
TRPC1 Link TRPV6 Fluorescence resonance energy transfer HEK293 Human Full-length Rat Full-length 22932896
TRPC1 Link VAMP Co-immunoprecipitation Human platelets 15121806
TRPC1 Link α-actinin-1 Co-immunoprecipitation Human platelets 17892531
TRPC1 Link α1-syntrophin Co-immunoprecipitation SolD6 19812031
TRPC1 Link α1-syntrophin Co-immunoprecipitation C57BL/10 mouse muscle cell 19812031
TRPC1 Link α1-syntrophin Co-immunoprecipitation Mouse muscle lysates 17202249
TRPC1 Link α1-syntrophin Co-immunoprecipitation SolC1 Not used Mouse Full-length 17202249
TRPC1 Link α1-syntrophin Co-immunoprecipitation SolD6 Not used Mouse Full-length 17202249
TRPC1 Link β-tubulin-5 Co-immunofluorescence staining ARPE-19 Human Full-length Not used 15935109
TRPC1 Link β-tubulin-5 Co-immunoprecipitation ARPE-19 Human Full-length Not used 15935109
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Characterization Toggle
  Binding region mapping Stoichiometry Affinity (Kd) Reference
TRP channel Interactor
TRP channel Interactor Method Species Region Species Region
TRPC1 Link Calmodulin Fluorescence probe labeling Human 720-749 Not specified Not determined 30 nM 11290752
TRPC1 Link Calmodulin Fusion protein-pull down assay Human 719-751 Not specified Not determined 11290752
TRPC1 Link Calmodulin Fusion protein-pull down assay Human 719-751 Not specified Not determined 11983166
TRPC1 Link Calmodulin Fusion protein-pull down assay Human 758-793 Not specified Not determined 11983166
TRPC1 Link Caveolin-1 Co-immunoprecipitation Human 781-789 Human 82-101 19052258
TRPC1 Link Caveolin-1 Co-immunoprecipitation Human 781-789 Human Not determined 16822931
TRPC1 Link Caveolin-1 Fusion protein-pull down assay Human Not determined Human 82-101 16822931
TRPC1 Link Caveolin-1 Yeast two-hybrid Human 271-349 Not specified Not determined 12732636
TRPC1 Link D2R Yeast two-hybrid Human 726-745 Human 131-151 18261457
TRPC1 Link Homer-3 Co-immunoprecipitation Human 645-648 Human EVH1 domain 14505576
TRPC1 Link Homer-3 Fusion protein-pull down assay Human 20-23 Not specified EVH1 domain 14505576
TRPC1 Link IP3R3 Co-immunoprecipitation Human 781-789 Human Not determined 19052258
TRPC1 Link IP3R3 Co-immunoprecipitation Human 645-648 Human Not determined 14505576
TRPC1 Link IP3R3 Fusion protein-pull down assay Human 719-751 Human 669-698 11290752
TRPC1 Link STIM1 Co-immunoprecipitation Rat Not determined Rat 1798-1887 22201561
TRPC1 Link STIM1 Co-immunoprecipitation Human Not determined Human 251-535 16906149
TRPC1 Link STIM1 Fusion protein-pull down assay Human Not determined Human 251-535 16906149
TRPC1 Link STIM1 Fusion protein-pull down assay Human 1-347 Human Not determined 17224452
TRPC1 Link TRPC3 Yeast two-hybrid Not specified 1-73 Not specified 1-341 15834157
TRPC1 Link TRPP1 Atomic force microscopy(AFM) analysis 2:2 19850920
TRPC1 Link TRPP1 Atomic force microscopy(AFM) analysis 2:2 19193631
TRPC1 Link TRPP1 Co-immunoprecipitation Human Not determined Human 1-643 10097141
TRPC1 Link TRPP1 Co-immunoprecipitation Human Not determined Human 679-968 10097141
TRPC1 Link TRPP1 Yeast two-hybrid Human 639-750 Human 822-895 10097141
TRPC1 Link TRPV4 Fluorescence resonance energy transfer 2:2 21871867
TRPC1 Link TRPV6 Fluorescence resonance energy transfer Human 1-193 Rat 1-198 22932896
TRPC1 Link α1-syntrophin Fusion protein-pull down assay Mouse Not determined Mouse 75-170 19812031
TRPC1 Link α1-syntrophin Fusion protein-pull down assay Mouse Not determined Not specified 75-170 17202249
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Functional consequence Toggle
TRP channel Interactor Method Post-translational modification Subcellular trafficking Activity Reference
TRPC1 Link Calmodulin Calcium measurement Inhibition 11983166
TRPC1 Link Calmodulin Patch clamp Inhibition 11983166
TRPC1 Link Caveolin-1 Cell surface biotinylation Increase in plasma membrane level 19897728
TRPC1 Link D2R Cell surface biotinylation Increase in plasma membrane level 18261457
TRPC1 Link FKBP52/FKBP4 Patch clamp Inhibition 19945390
TRPC1 Link I-MFA Patch clamp Inhibition 14530267
TRPC1 Link IP3R2 Calcium measurement Activation 12196544
TRPC1 Link IP3R2 Patch clamp Activation 12196544
TRPC1 Link MGLUR1 Patch clamp Activation 14614461
TRPC1 Link PLCγ1 Calcium measurement Activation 15654973
TRPC1 Link STIM1 Patch clamp Activation 16906149
TRPC1 Link TRPC3 Patch clamp New channel creation 10882720
TRPC1 Link TRPC4 Patch clamp New channel creation 11301024
TRPC1 Link TRPC4 Patch clamp New channel creation 22144671
TRPC1 Link TRPC5 Patch clamp New channel creation 12857742
TRPC1 Link TRPC5 Patch clamp New channel creation 11301024
TRPC1 Link TRPP1 Patch clamp New channel creation 18323855
TRPC1 Link TRPV4 Cell surface biotinylation Increase in plasma membrane level 20705915
TRPC1 Link TRPV4 Co-immunofluorescence staining Increase in plasma membrane level 20705915
TRPC1 Link β-tubulin-5 Calcium measurement Inhibition 15935109
TRPC1 Link β-tubulin-5 Co-immunofluorescence staining Increase in plasma membrane level 15935109
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

To prevent spam comments, we use reCAPTCHA. Please type correct words into the following box.