TRPM1 / interactors

Name: Transient receptor potential cation channel subfamily M member 1 (TRPM1)
Official Symbol: TRPM1 provided by HGNC
Function:
Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression (By similarity). May act as a spontaneously active, calcium-permeable plasma membrane channel.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).
Species External DB Questionmark
Entrez Gene UniprotKB DIP IntAct MINT BioGRID STRING IUPHAR-DB KEGG OMIM
Human
Seq		 4308External Q7Z4N2External       110453External Q7Z4N2External 493External hsa:4308External 603576External
Mouse
Seq		 17364External Q2TV84External       201440External     mmu:17364External  
Rat
Seq		 361586External Q2WEA5External       262795External Q2WEA5External   rno:361586External  
PPI pairs:
Biological Process:
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Screening Toggle
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPM1 Link Nyctalopin Inference Prediction 21734298
TRPM1 Link TRPM3 Inference Prediction 21278253
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Validation: In vitro validation Toggle
  Assay with recombinant proteins Reference
TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Expression system Species Region Expression system
TRPM1 Link Nyctalopin Yeast two-hybrid Mouse Full-length Yeast Mouse Full-length Yeast 21734298
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Validation: In vivo validation Toggle
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPM1 Link Nyctalopin Co-immunofluorescence staining Mouse retinal section Mouse Full-length Mouse Full-length 21734298
TRPM1 Link Nyctalopin Co-immunoprecipitation HEK293T Mouse Full-length Mouse Full-length 21734298
TRPM1 Link Nyctalopin Co-immunoprecipitation HEK293T Mouse Full-length Mouse Full-length 21832182
TRPM1 Link TRPM3 Co-immunoprecipitation HEK293 Rat Full-length Mouse Full-length 21278253
TRPM1 Link TRPM3 Fluorescence resonance energy transfer HEK293 Rat Full-length Mouse Full-length 21278253
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Functional consequence Toggle
TRP channel Interactor Method Post-translational modification Subcellular trafficking Activity Reference
TRPM1 Link Nyctalopin Patch clamp Activation 21734298
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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