TRPM3 / interactors

Name: Transient receptor potential cation channel subfamily M member 3 (TRPM3)
Official Symbol: TRPM3 provided by HGNC
Function:
Calcium channel mediating constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by store depletion and muscarinic receptor activation.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).
Species External DB Questionmark
Entrez Gene UniprotKB DIP IntAct MINT BioGRID STRING IUPHAR-DB KEGG OMIM
Human
Seq		 80036External Q9HCF6External       123085External Q9HCF6External 495External hsa:80036External 608961External
Mouse
Seq		 226025External Q5F4S6External       230459External Q5F4S6External   mmu:226025External  
Rat
Seq		 309407External A7L637External       259372External A7L637External   rno:309407External  
Biological Process: No information in Gene Ontology
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Screening Toggle
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPM3 Link Calmodulin Inference Prediction 22451665
TRPM3 Link S100A10 Inference Prediction 22451665
TRPM3 Link TRPM1 Inference Prediction 21278253
TRPM3 Link UBC Affinity purification-mass spectrometry Not used as a bait Human HEK293T Cell lystaes 21890473
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Validation: In vitro validation Toggle
  Assay with recombinant proteins Reference
TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Expression system Species Region Expression system
TRPM3 Link Calmodulin Fluorescence probe labeling Human 35-124 E. coli Not specified Not specified Not specified 22451665
TRPM3 Link Calmodulin Fluorescence probe labeling Human 291-382 E. coli Not specified Not specified Not specified 22451665
TRPM3 Link S100A10 Fluorescence probe labeling Human 35-124 E. coli Human Full-length E. coli 22451665
TRPM3 Link S100A10 Fluorescence probe labeling Human 291-382 E. coli Human Full-length E. coli 22451665
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Validation: In vivo validation Toggle
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPM3 Link TRPM1 Co-immunoprecipitation HEK293 Mouse Full-length Rat Full-length 21278253
TRPM3 Link TRPM1 Fluorescence resonance energy transfer HEK293 Mouse Full-length Rat Full-length 21278253
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Characterization Toggle
  Binding region mapping Stoichiometry Affinity (Kd) Reference
TRP channel Interactor
TRP channel Interactor Method Species Region Species Region
TRPM3 Link Calmodulin Fluorescence probe labeling Human 291-382 Not specified Not determined 22451665
TRPM3 Link Calmodulin Fluorescence probe labeling Human 35-124 Not specified Not determined 22451665
TRPM3 Link S100A10 Fluorescence probe labeling Human 291-382 Human Not determined 22451665
TRPM3 Link S100A10 Fluorescence probe labeling Human 35-124 Human Not determined 22451665
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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