TRPML2 / interactors

Name: Mucolipin-2 (TRPML2)
Official Symbol: MCOLN2 provided by HGNC
Function:
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).
Species External DB Questionmark
Entrez Gene UniprotKB DIP IntAct MINT BioGRID STRING IUPHAR-DB KEGG OMIM
Human
Seq		 255231External Q8IZK6External       129087External Q8IZK6External 502External hsa:255231External 607399External
Mouse
Seq		 68279External Q8K595External       212782External Q8K595External   mmu:68279External  
Rat
Seq		 292168External Q499S1External       253788External     rno:292168External  
PPI pairs:
Biological Process: No information in Gene Ontology
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Screening Toggle
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPML2 Link HSC70 Inference Prediction 19117012
TRPML2 Link TRPML1 Inference Prediction 16606612
TRPML2 Link TRPML3 Inference Prediction 16606612
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Validation: In vivo validation Toggle
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPML2 Link HSC70 Co-immunoprecipitation CHO Human Full-length Not used 19117012
TRPML2 Link TRPML1 Co-immunofluorescence staining HEK293 19557826
TRPML2 Link TRPML1 Co-immunofluorescence staining CHO Human Full-length Human Full-length 19885840
TRPML2 Link TRPML1 Co-immunoprecipitation HEK293 Human Full-length (mutation in the pore region) Human Full-length (mutation in the pore region) 20736310
TRPML2 Link TRPML1 Co-immunoprecipitation HEK293 19557826
TRPML2 Link TRPML1 Co-immunoprecipitation CHO Human Full-length Human Full-length 19885840
TRPML2 Link TRPML1 Fluorescence resonance energy transfer HEK293 Human Full-length Human Full-length 16606612
TRPML2 Link TRPML3 Co-immunofluorescence staining HEK293 19557826
TRPML2 Link TRPML3 Co-immunoprecipitation HEK293 Human Full-length (mutation in the pore region) Human Full-length (mutation in the pore region) 20736310
TRPML2 Link TRPML3 Co-immunoprecipitation HEK293 19557826
TRPML2 Link TRPML3 Fluorescence resonance energy transfer HEK293 Human Full-length Mouse Full-length 16606612
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 Screening Arrow2 Validation: In vitro validation Arrow2 Validation: In vivo validation Arrow2 Characterization Arrow2 Functional consequence Arrow2 top
Functional consequence Toggle
TRP channel Interactor Method Post-translational modification Subcellular trafficking Activity Reference
TRPML2 Link TRPML1 Patch clamp New channel creation 19885840
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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