TRPML3 / interactors

Name: Mucolipin-3 (TRPML3)
Official Symbol: MCOLN3 provided by HGNC
Function:
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).
Species External DB Questionmark
Entrez Gene UniprotKB DIP IntAct MINT BioGRID STRING IUPHAR-DB KEGG OMIM
Human
Seq
55283External Q8TDD5External       120571External Q8TDD5External 503External hsa:55283External 607400External
Mouse
Seq
171166External Q8R4F0External       228482External Q8R4F0External   mmu:171166External  
Rat
Seq
308022External Q6AY44External DIP-39439NExternal Q6AY44External   258885External Q6AY44External   rno:308022External  
Biological Process:
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
Screening Toggle
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPML3 Link HSC70 Inference Prediction 19117012
TRPML3 Link TPC1 Inference Prediction 21540176
TRPML3 Link TPC2 Inference Prediction 21540176
TRPML3 Link TRPML1 Inference Prediction 16606612
TRPML3 Link TRPML2 Inference Prediction 16606612
TRPML3 Link TRPV5 Inference Prediction 23469151
TRPML3 Link TRPV6 Inference Prediction 23469151
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Validation: In vivo validation Toggle
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPML3 Link HSC70 Co-immunoprecipitation CHO Human Full-length Not used 19117012
TRPML3 Link TPC1 Co-immunofluorescence staining HEK293T Human Full-length Human Full-length 21540176
TRPML3 Link TPC1 Co-immunofluorescence staining HeLa Human Full-length Human Full-length 21540176
TRPML3 Link TPC1 Co-immunofluorescence staining SK-BR-3 Human Full-length Human Full-length 21540176
TRPML3 Link TPC1 Co-immunoprecipitation HEK293T Human Full-length Human Full-length 21540176
TRPML3 Link TPC2 Co-immunofluorescence staining HEK293T Human Full-length Human Full-length 21540176
TRPML3 Link TPC2 Co-immunofluorescence staining HeLa Human Full-length Human Full-length 21540176
TRPML3 Link TPC2 Co-immunofluorescence staining SK-BR-3 Human Full-length Human Full-length 21540176
TRPML3 Link TPC2 Co-immunoprecipitation HEK293T Human Full-length Human Full-length 21540176
TRPML3 Link TRPML1 Co-immunofluorescence staining CHO Human Full-length Human Full-length 19885840
TRPML3 Link TRPML1 Co-immunofluorescence staining HEK293 19557826
TRPML3 Link TRPML1 Co-immunoprecipitation CHO Human Full-length Human Full-length 19885840
TRPML3 Link TRPML1 Co-immunoprecipitation HEK293 Human Full-length (mutation in the pore region) Human Full-length (mutation in the pore region) 20736310
TRPML3 Link TRPML1 Co-immunoprecipitation HEK293 Human Full-length Not specified Full-length 19522758
TRPML3 Link TRPML1 Co-immunoprecipitation HEK293 19557826
TRPML3 Link TRPML1 Fluorescence resonance energy transfer HEK293 Not specified Full-length Not specified Full-length 23469151
TRPML3 Link TRPML1 Fluorescence resonance energy transfer HEK293 Mouse Full-length Human Full-length 16606612
TRPML3 Link TRPML2 Co-immunofluorescence staining HEK293 19557826
TRPML3 Link TRPML2 Co-immunoprecipitation HEK293 Human Full-length (mutation in the pore region) Human Full-length (mutation in the pore region) 20736310
TRPML3 Link TRPML2 Co-immunoprecipitation HEK293 19557826
TRPML3 Link TRPML2 Fluorescence resonance energy transfer HEK293 Not specified Full-length Not specified Full-length 23469151
TRPML3 Link TRPML2 Fluorescence resonance energy transfer HEK293 Mouse Full-length Human Full-length 16606612
TRPML3 Link TRPV5 Fluorescence resonance energy transfer HEK293 Not specified Full-length Mouse Full-length 23469151
TRPML3 Link TRPV6 Fluorescence resonance energy transfer HEK293 Not specified Full-length Not specified Full-length 23469151
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Characterization Toggle
  Binding region mapping Stoichiometry Affinity (Kd) Reference
TRP channel Interactor
TRP channel Interactor Method Species Region Species Region
TRPML3 Link TRPV5 Patch clamp 1:1 23469151
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Functional consequence Toggle
TRP channel Interactor Method Post-translational modification Subcellular trafficking Activity Reference
TRPML3 Link TRPML1 Co-immunofluorescence staining Increase in lysosomal membrane level 16606612
TRPML3 Link TRPML1 Patch clamp New channel creation 19885840
TRPML3 Link TRPML2 Co-immunofluorescence staining Increase in lysosomal membrane level 16606612
TRPML3 Link TRPV5 Patch clamp New channel creation 23469151
(Link: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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