TRP channels

TRPC
- TRPC1
- TRPC2
- TRPC3
- TRPC4
- TRPC5
- TRPC6
- TRPC7
TRPV
- TRPV1
- TRPV2
- TRPV3
- TRPV4
- TRPV5
- TRPV6
TRPM
- TRPM1
- TRPM2
- TRPM3
- TRPM4
- TRPM5
- TRPM6
- TRPM7
- TRPM8
TRPML
- TRPML1
- TRPML2
- TRPML3
TRPP
- TRPP1
- TRPP2
- TRPP3
TRPA
- TRPA1

» Citation

TRPP1 / interactors

At a glance
In detail

Basic Information
External Database
PPI pairs (113)
Biological Process (41)
Disease (1)

Name: Polycystin-2 (TRPP1)

Official Symbol: PKD2 provided by HGNC

Function:

Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis (By similarity). Acts as a regulator of cilium length, together with PKD1 (By similarity). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity). Functions as a calcium permeable cation channel.

Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species

External DB

Entrez Gene

UniprotKB

DIP

IntAct

MINT

BioGRID

STRING

IUPHAR-DB

KEGG

OMIM

Human

Mouse

Rat

PPI pairs:

80K-H	ABHD12	ATP13A1	BAG2	BRI3BP	CD2AP	CDKAL1	CISD2
Calnexin	Cullin-1	DHRS7B	DIAP1/DRF1	DNAJA1	EGFR	EPHA2	ERLIN2
FAF2	Filamin-A	H2-D1	H2-K1	HAX-1	HERP	ID2	IFIT1
IFT57	IP3R1	IP3R3	KIF3A	KIF3B	KIM1/TIM1	KRAS	LAP2/TMPO
LETMD1	MGST1	NEK8	Numb	Nup155	PACS-1	PACS-2	PDIA3/GRP58
PERK	PGAM5	PIGEA-14/CBY1	PKD1/Polycystin-1	PKD1L1/Polycystin-1L1	PKHD1/FPC	PLCγ2	PSMD7
PTP1B	Paraoxonase 3	Pericentrin	RAB12	RAB14	RAB18	RAB21	RAB7
RAD50	RCHY1/PIRH2	RP2	RTP4	Ribophorin I	Ribophorin II	RyR2	SEC22B
SEC61B	SERCA2	SGPL1	SKP1	SRPRB	SSFA2	ST7	SUN3
Syntaxin5	TAP1	TAP2	TAZ/WWTR1	TBL2	TFRC	TMEM120a	TMEM209
TMEM48/NDC1	TMEM59	TOR1AIP1/LAB1B	TRIM59	TRPC1	TRPC3	TRPC4	TRPC7
TRPV4	TTC35	TYW1	Tapasin	Tropomyosin 1	Troponin I 1	Troponin I 2	Troponin I 3
UBC	UHRF1	USE1	VAMPA	VAMPB	VDAC3	VRK2	VTI1B
Viperin	eIF2α	p97/VCP	α-actinin	α-actinin-1	α-actinin-2	β-Trcp1	β-Trcp2
γ-adaptin

Biological Process:

GO:0035904 : aorta development
GO:0001658 : branching involved in ureteric bud morphogenesis
GO:0007050 : cell cycle arrest
GO:0071498 : cellular response to fluid shear stress
GO:0071464 : cellular response to hydrostatic pressure
GO:0071470 : cellular response to osmotic stress
GO:0034614 : cellular response to reactive oxygen species
GO:0051298 : centrosome duplication
GO:0042994 : cytoplasmic sequestering of transcription factor
GO:0050982 : detection of mechanical stimulus
GO:0003127 : detection of nodal flow
GO:0061371 : determination of heart left/right asymmetry
GO:0001892 : embryonic placenta development
GO:0007507 : heart development
GO:0007259 : JAK-STAT cascade
GO:0001889 : liver development
GO:0072177 : mesonephric duct development
GO:0072218 : metanephric ascending thin limb development
GO:0072214 : metanephric cortex development
GO:0072219 : metanephric cortical collecting duct development
GO:0072235 : metanephric distal tubule development
GO:0072075 : metanephric mesenchyme development
GO:0072284 : metanephric S-shaped body morphogenesis
GO:0072208 : metanephric smooth muscle tissue development
GO:0035502 : metanephric ureteric bud development
GO:0008285 : negative regulation of cell proliferation
GO:2000134 : negative regulation of G1/S transition of mitotic cell cycle
GO:0060315 : negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0021915 : neural tube development
GO:0060674 : placenta blood vessel development
GO:0071158 : positive regulation of cell cycle arrest
GO:0031659 : positive regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0031587 : positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0045429 : positive regulation of nitric oxide biosynthetic process
GO:0045944 : positive regulation of transcription from RNA polymerase II promoter
GO:0090279 : regulation of calcium ion import
GO:0030814 : regulation of cAMP metabolic process
GO:0051209 : release of sequestered calcium ion into cytosol
GO:0061441 : renal artery morphogenesis
GO:0061333 : renal tubule morphogenesis
GO:0021510 : spinal cord development

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/

Disease:

OMIM:173910 : Polycystic kidney disease 2 (OMIM:613095 )

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening

Validation: In vitro validation

Validation: In vivo validation

Characterization

Functional consequence

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Screening
			Experimental screening					Non-experimental screening	Reference
			TRP channel construct		Interactor source
TRP channel	Interactor	Method	Species	Region	Species	Organ/tissue	Sample type
TRPP1	80K-H	Inference						Prediction	19801576
TRPP1	ABHD12	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	ATP13A1	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	BAG2	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	BRI3BP	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	Calnexin	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	CD2AP	Yeast two-hybrid	Mouse	680-968	Mouse	Embryonic	cDNA library		10913159
TRPP1	CDKAL1	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	CISD2	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	Cullin-1	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	cullin-1	Inference						Prediction	17636028
TRPP1	DHRS7B	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	DIAP1/DRF1	Yeast two-hybrid	Human	851-968	Mouse	Embryonic	cDNA library		15123714
TRPP1	DNAJA1	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	EGFR	Inference						Prediction	16135816
TRPP1	eIF2α	Inference						Prediction	18664456
TRPP1	EPHA2	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	ERLIN2	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	FAF2	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	Filamin-A	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	H2-D1	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	H2-K1	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	HAX-1	Yeast two-hybrid	Human	618-658	Mouse	Embryonic	cDNA library		10760273
TRPP1	HAX-1	Yeast two-hybrid	Human	618-658	Human	Kidney	cDNA library		10760273
TRPP1	HERP	Inference						Prediction	18178578
TRPP1	ID2	Yeast two-hybrid	Human	679-968	Human	Fetal kidney	cDNA library		16311606
TRPP1	IFIT1	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	IFT57	Inference						Prediction	15337773
TRPP1	IP3R1	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	IP3R1	Inference						Prediction	16223735
TRPP1	IP3R3	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	KIF3A	Inference						Prediction	16950792
TRPP1	KIF3B	Yeast two-hybrid	Human	682-968	Human	Heart	cDNA library		16950792
TRPP1	KIF3B	Yeast two-hybrid	Human	682-968	Human	Heart	cDNA library		17008358
TRPP1	KIM1/TIM1	Inference						Prediction	18273441
TRPP1	KRAS	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	LAP2/TMPO	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	LETMD1	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	MGST1	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	NEK8	Inference						Prediction	18235101
TRPP1	Numb	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	Nup155	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	p97/VCP	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	p97/VCP	Inference						Prediction	18178578
TRPP1	PACS-1	Inference						Prediction	15692563
TRPP1	PACS-2	Inference						Prediction	15692563
TRPP1	Paraoxonase 3	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	PDIA3/GRP58	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	Pericentrin	Inference						Prediction	15337773
TRPP1	PERK	Inference						Prediction	18664456
TRPP1	PGAM5	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	PIGEA-14/CBY1	Yeast two-hybrid	Human	680-968	Human	Kidney	cDNA library		15194699
TRPP1	PKD1/Polycystin-1	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	PKD1/Polycystin-1	Inference						Prediction	9171830
TRPP1	PKD1L1/Polycystin-1L1	Inference						Prediction	21307093
TRPP1	PKHD1/FPC	Inference						Prediction	17008358
TRPP1	PLCγ2	Inference						Prediction	16135816
TRPP1	PSMD7	Inference						Prediction	18178578
TRPP1	PTP1B	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	RAB12	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	RAB14	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	RAB18	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	RAB21	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	RAB7	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	RAD50	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	RCHY1/PIRH2	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	Ribophorin I	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	Ribophorin II	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	RP2	Inference						Prediction	20729296
TRPP1	RTP4	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	RyR2	Inference						Prediction	17404231
TRPP1	SEC22B	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	SEC61B	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	SERCA2	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	SGPL1	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	SKP1	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	SRPRB	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	SSFA2	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	ST7	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	SUN3	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	Syntaxin5	Yeast two-hybrid	Human	3-213	Mouse	Embryonic	cDNA library		18836075
TRPP1	TAP1	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	TAP2	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	Tapasin	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	TAZ/WWTR1	Inference						Prediction	17636028
TRPP1	TBL2	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	TFRC	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	TMEM120a	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	TMEM209	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	TMEM48/NDC1	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	TMEM59	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	TOR1AIP1/LAB1B	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	TRIM59	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	Tropomyosin 1	Yeast two-hybrid	Human	682-968	Human	Heart	cDNA library		12527301
TRPP1	Troponin I 1	Inference						Prediction	12525172
TRPP1	Troponin I 2	Inference						Prediction	12525172
TRPP1	Troponin I 3	Yeast two-hybrid	Human	682-968	Human	Heart	cDNA library		12525172
TRPP1	TRPC1	Inference						Prediction	10097141
TRPP1	TRPC3	Inference						Prediction	19812035
TRPP1	TRPC4	Inference						Prediction	18256307
TRPP1	TRPC7	Inference						Prediction	19812035
TRPP1	TRPV4	Inference						Prediction	18695040
TRPP1	TTC35	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	TYW1	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	UBC	Inference						Prediction	18178578
TRPP1	UHRF1	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	USE1	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	VAMPA	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	VAMPB	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	VDAC3	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	Viperin	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	VRK2	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	VTI1B	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	α-actinin	Inference						Prediction	15843396
TRPP1	α-actinin-1	Inference						Prediction	15843396
TRPP1	α-actinin-2	Yeast two-hybrid	Human	1-215	Human	Heart	cDNA library		15843396
TRPP1	β-Trcp1	Inference						Prediction	17636028
TRPP1	β-Trcp2	Affinity purification-mass spectrometry	Mouse	Not specified	Mouse	Vascular smooth muscle	MOVAS lysates		19879844
TRPP1	β-Trcp2	Inference						Prediction	17636028
TRPP1	γ-adaptin	Inference						Prediction	15692563

(

: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening

Validation: In vitro validation

Validation: In vivo validation

Characterization

Functional consequence

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Validation: In vitro validation
			Assay with recombinant proteins						Reference
			TRP channel construct			Interactor construct
TRP channel	Interactor	Method	Species	Region	Expression system	Species	Region	Expression system
TRPP1	CD2AP	Fusion protein-pull down assay	Mouse	747-968	E. coli	Mouse	331-637	E. coli	10913159
TRPP1	HAX-1	Yeast two-hybrid	Human	618-658	Yeast	Mouse	94-280	Yeast	10760273
TRPP1	ID2	Yeast two-hybrid	Human	679-968	Yeast	Human	1-134	Yeast	16311606
TRPP1	KIF3A	Fusion protein-pull down assay	Human	682-968	E. coli	Human	Full-length	In vitro translation	16950792
TRPP1	KIF3A	Yeast two-hybrid	Human	682-968	Yeast	Human	Full-length	Yeast	16950792
TRPP1	KIF3B	Fusion protein-pull down assay	Human	1-215	E. coli	Not used		Mouse inner medullary collecting duct cell lysates	17008358
TRPP1	KIF3B	Fusion protein-pull down assay	Human	682-968	E. coli	Not used		Mouse inner medullary collecting duct cell lysates	17008358
TRPP1	PACS-1	Fusion protein-pull down assay	Human	Full-length	HEK293T lysates	Human	Full-length	Not specified	15692563
TRPP1	PACS-1	Fusion protein-pull down assay	Not used		Mouse kidney tissue lysates	Human	Full-length	Not specified	15692563
TRPP1	PACS-2	Fusion protein-pull down assay	Human	Full-length	HEK293T lysates	Human	Full-length	Not specified	15692563
TRPP1	PKD1/Polycystin-1	Yeast two-hybrid	Human	680-968	Yeast	Human	1114-1339	Yeast	9192675
TRPP1	PKD1/Polycystin-1	Yeast two-hybrid	Human	687-968	Yeast	Human	4088-4302	Yeast	9171830
TRPP1	RyR2	Fusion protein-pull down assay	Human	1-703	MDCK lysates	Not used		Mouse cardiac tissue microsome	17404231
TRPP1	Syntaxin5	Fusion protein-pull down assay	Human	3-213	E. coli	Mouse	Full-length	Not specified	18836075
TRPP1	TAZ/WWTR1	Fusion protein-pull down assay	Mouse	678-966	E. coli	Mouse	1-395	HEK293 lysates	17636028
TRPP1	Tropomyosin 1	Fusion protein-pull down assay	Human	682-968	E. coli	Human	Full-length	E. coli	12527301
TRPP1	Troponin I 3	Fusion protein-pull down assay	Human	682-968	E. coli	Human	Full-length	E. coli	12525172
TRPP1	TRPC1	Fusion protein-pull down assay	Human	680-968	In vitro translation	Human	662-750	E. coli	10097141
TRPP1	α-actinin-1	Fusion protein-pull down assay	Human	1-215	E. coli	Chicken	Not specified	Not specified	15843396
TRPP1	α-actinin-1	Fusion protein-pull down assay	Human	821-968	E. coli	Chicken	Not specified	Not specified	15843396
TRPP1	α-actinin-2	Fusion protein-pull down assay	Human	1-215	E. coli	Chicken	Not specified	Not specified	15843396
TRPP1	α-actinin-2	Fusion protein-pull down assay	Human	821-968	E. coli	Chicken	Not specified	Not specified	15843396

(

: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening

Validation: In vitro validation

Validation: In vivo validation

Characterization

Functional consequence

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Validation: In vivo validation
			Assay with endogenous proteins	Assay with overexpressed proteins					Reference
			Cell or tissue	Cell or tissue	TRP channel construct		Interactor construct
TRP channel	Interactor	Method	Cell or tissue	Cell or tissue	Species	Region	Species	Region
TRPP1	80K-H	Co-immunofluorescence staining		HeLa	Human	Full-length	Not used		19801576
TRPP1	80K-H	Co-immunoprecipitation		HEK293T	Human	Full-length	Human	Full-length	19801576
TRPP1	CD2AP	Co-immunofluorescence staining	M-1 cell						10913159
TRPP1	CD2AP	Co-immunofluorescence staining		LLC-PK1	Human	Full-length	Mouse	Full-length	10913159
TRPP1	CD2AP	Co-immunoprecipitation	M-1 cell						10913159
TRPP1	cullin-1	Co-immunoprecipitation	Mouse Inner medullary collecting duct cell						17636028
TRPP1	DIAP1/DRF1	Co-immunofluorescence staining	LLC-PK1						15123714
TRPP1	DIAP1/DRF1	Co-immunoprecipitation	HEK293						15123714
TRPP1	EGFR	Co-immunofluorescence staining	LLC-PK1						16135816
TRPP1	EGFR	Co-immunoprecipitation		HEK293T	Human	Full-length	Human	Full-length	16135816
TRPP1	eIF2α	Co-immunofluorescence staining		HEK293T	Human	Full-length	Not used		18664456
TRPP1	eIF2α	Co-immunoprecipitation	Mouse Inner medullary collecting duct						18664456
TRPP1	Filamin-A	Co-immunoprecipitation	COS-7						19879844
TRPP1	HAX-1	Co-immunofluorescence staining		HeLa	Human	Full-length	Mouse	Full-length	10760273
TRPP1	HAX-1	Co-immunoprecipitation		HeLa	Human	Full-length	Mouse	Full-length	10760273
TRPP1	HERP	Co-immunoprecipitation		HeLa	Human	Full-length	Mouse	Full-length	18178578
TRPP1	HERP	Co-immunoprecipitation		HEK293T	Human	Full-length	Mouse	Full-length	19801576
TRPP1	ID2	Co-immunofluorescence staining		HEK293T	Human	Full-length	Not used		16311606
TRPP1	ID2	Co-immunoprecipitation		HEK293T	Human	Full-length	Not used		16311606
TRPP1	IFT57	Co-immunoprecipitation	Tg737 Mouse 488 epithelial cell						15337773
TRPP1	IP3R1	Co-immunofluorescence staining		LLC-PK1	Human	Full-length	Not used		20375013
TRPP1	IP3R1	Co-immunoprecipitation		LLC-PK1	Human	Full-length	Not used		20375013
TRPP1	IP3R1	Co-immunoprecipitation		COS-7	Human	Full-length	Not used		16223735
TRPP1	IP3R1	Co-immunoprecipitation		Xenopus oocyte	Human	1-741	Not used		16223735
TRPP1	IP3R1	Co-immunoprecipitation		Xenopus oocyte	Human	Full-length	Not used		16223735
TRPP1	IP3R3	Co-immunofluorescence staining		LLC-PK1	Human	Full-length	Not used		20375013
TRPP1	IP3R3	Co-immunoprecipitation		LLC-PK1	Human	Full-length	Not used		20375013
TRPP1	KIF3A	Co-immunofluorescence staining	Mouse Inner medullary collecting duct cell						16950792
TRPP1	KIF3A	Co-immunofluorescence staining	MDCK						16950792
TRPP1	KIF3A	Co-immunofluorescence staining	LLC-PK1						16950792
TRPP1	KIF3A	Co-immunoprecipitation	MDCK						17283055
TRPP1	KIF3B	Co-immunofluorescence staining	Mouse inner medullary collecting duct cell						17008358
TRPP1	KIF3B	Co-immunoprecipitation	MDCK						17008358
TRPP1	KIF3B	Co-immunoprecipitation	Mouse inner medullary collecting duct cell						17008358
TRPP1	KIF3B	Co-immunoprecipitation	Human kidney lysates						17008358
TRPP1	KIM1/TIM1	Co-immunoprecipitation		HEK293T	Human	Full-length	Human	Full-length	18273441
TRPP1	NEK8	Co-immunofluorescence staining	Mouse kidney section						18235101
TRPP1	NEK8	Co-immunoprecipitation	Mouse kidney tissue						18235101
TRPP1	NEK8	Co-immunoprecipitation	Mouse Inner medullary collecting duct cell						18235101
TRPP1	p97/VCP	Co-immunofluorescence staining		MDCK	Human	Full-length	Not used		18178578
TRPP1	p97/VCP	Co-immunoprecipitation	Mouse Inner medullary collecting duct cell						18178578
TRPP1	PACS-1	Co-immunoprecipitation	COS M6 kidney cell						15692563
TRPP1	PACS-2	Co-immunoprecipitation	COS M6 kidney cell						15692563
TRPP1	Pericentrin	Co-immunofluorescence staining	RPE1						15337773
TRPP1	Pericentrin	Co-immunoprecipitation	RPE1						15337773
TRPP1	PERK	Co-immunoprecipitation	Mouse Inner medullary collecting duct						18664456
TRPP1	PERK	Co-immunoprecipitation		HEK293T	Not used		Mouse	Full-length	18664456
TRPP1	PERK	Co-immunoprecipitation		HEK293T	Human	Full-length	Not used		18664456
TRPP1	PIGEA-14/CBY1	Co-immunofluorescence staining		HeLa	Human	Full-length	Human	Full-length	15194699
TRPP1	PIGEA-14/CBY1	Co-immunoprecipitation		LLC-PK1	Human	Full-length	Human	Full-length	15194699
TRPP1	PKD1/Polycystin-1	Co-immunofluorescence staining		CHO	Human	Full-length	Human	Full-length	11140688
TRPP1	PKD1/Polycystin-1	Co-immunofluorescence staining		PKD2-/- transgenic mouse kidney tissue	Human	Full-length	Mouse	Full-length	12840011
TRPP1	PKD1/Polycystin-1	Co-immunofluorescence staining	Mouse vascular smooth muscle cell						12937304
TRPP1	PKD1/Polycystin-1	Co-immunofluorescence staining		CHO	Human	Full-length	Human	Full-length	15060061
TRPP1	PKD1/Polycystin-1	Co-immunoprecipitation		CHO	Human	Full-length	Human	Full-length	11140688
TRPP1	PKD1/Polycystin-1	Co-immunoprecipitation		COS-7	Human	Full-length	Mouse	4182-4293	12840011
TRPP1	PKD1/Polycystin-1	Co-immunoprecipitation	Mouse vascular smooth muscle cell						12937304
TRPP1	PKD1/Polycystin-1	Co-immunoprecipitation	COS-1						11901144
TRPP1	PKD1/Polycystin-1	Co-immunoprecipitation	Human kidney lysates						11901144
TRPP1	PKD1/Polycystin-1	Co-immunoprecipitation		HEK293T	Human	680-968	Human	1114-1339	9192675
TRPP1	PKD1L1/Polycystin-1L1	Co-immunofluorescence staining		IMCD3	Mouse	Full-length	Mouse	Full-length	21307093
TRPP1	PKD1L1/Polycystin-1L1	Co-immunoprecipitation		HEK293T	Mouse	Full-length	Mouse	Full-length	21307093
TRPP1	PKHD1/FPC	Co-immunoprecipitation		HEK293	Human	1-215	Human	3882-4074	18782757
TRPP1	PKHD1/FPC	Co-immunoprecipitation	Mouse kidney tissue						18235088
TRPP1	PKHD1/FPC	Co-immunoprecipitation		HEK293	Human	Full-length	Human	3872-4074	18235088
TRPP1	PKHD1/FPC	Co-immunoprecipitation	Mouse inner medulla collecting duct cell						17008358
TRPP1	PKHD1/FPC	Co-immunoprecipitation	Mouse kidney tissue						17283055
TRPP1	PKHD1/FPC	Co-immunoprecipitation	MDCK						17283055
TRPP1	PLCγ2	Co-immunoprecipitation		HEK293T	Human	Full-length	Not specified	Full-length	16135816
TRPP1	PSMD7	Co-immunoprecipitation	Mouse Inner medullary collecting duct cell						18178578
TRPP1	RP2	Co-immunoprecipitation	Bovine retinal extract						20729296
TRPP1	RP2	Co-immunoprecipitation		MDCK	Not used		Human	Full-length	20729296
TRPP1	RyR2	Co-immunoprecipitation	Mouse heart tissue						17404231
TRPP1	Syntaxin5	Co-immunofluorescence staining		LLC-PK1	Human	Full-length	Mouse	Full-length	18836075
TRPP1	Syntaxin5	Co-immunoprecipitation		LLC-PK1	Human	Full-length	Mouse	Full-length	18836075
TRPP1	TAZ/WWTR1	Co-immunoprecipitation		HEK293	Mouse	Full-length	Mouse	Full-length	17636028
TRPP1	TAZ/WWTR1	Co-immunoprecipitation	Mouse Inner medullary collecting duct cell						17636028
TRPP1	Tropomyosin 1	Co-immunofluorescence staining		NIH-3T3	Human	Full-length	Human	Full-length	12527301
TRPP1	Tropomyosin 1	Co-immunoprecipitation		NIH-3T3	Human	Full-length	Human	Full-length	12527301
TRPP1	Tropomyosin 1	Co-immunoprecipitation		Xenopus oocyte	Human	Full-length	Human	Full-length	12527301
TRPP1	Tropomyosin 1	Co-immunoprecipitation	HEK293						12527301
TRPP1	Tropomyosin 1	Co-immunoprecipitation	Human kidney tissue						12527301
TRPP1	Troponin I 1	Co-immunoprecipitation		NIH-3T3	Human	Full-length	Human	Full-length	12525172
TRPP1	Troponin I 1	Co-immunoprecipitation		Xenopus oocyte	Human	Full-length	Human	Full-length	12525172
TRPP1	Troponin I 2	Co-immunoprecipitation		NIH-3T3	Human	Full-length	Human	Full-length	12525172
TRPP1	Troponin I 2	Co-immunoprecipitation		Xenopus oocyte	Human	Full-length	Human	Full-length	12525172
TRPP1	Troponin I 3	Co-immunoprecipitation		NIH-3T3	Human	Full-length	Human	Full-length	12525172
TRPP1	Troponin I 3	Co-immunoprecipitation		Xenopus oocyte	Human	Full-length	Human	Full-length	12525172
TRPP1	Troponin I 3	Co-immunoprecipitation	Human heart tissue						12525172
TRPP1	TRPC1	Co-immunofluorescence staining		HEK293 tsA 201	Human	Full-length	Human	Full-length	19850920
TRPP1	TRPC1	Co-immunofluorescence staining	mIMCD-3						18323855
TRPP1	TRPC1	Co-immunofluorescence staining		HEK293T	Human	Full-length	Human	Full-length	10097141
TRPP1	TRPC1	Co-immunoprecipitation		HEK293T	Not specified	Not specified	Human	Full-length	14530267
TRPP1	TRPC1	Co-immunoprecipitation		Human glomerular mesangial cell	Not used		Human	Full-length	18256307
TRPP1	TRPC1	Co-immunoprecipitation		HEK293	Human	Full-length	Mouse	Full-length	19812035
TRPP1	TRPC1	Co-immunoprecipitation		HEK293 tsA 201	Human	Full-length	Human	Full-length	19850920
TRPP1	TRPC1	Co-immunoprecipitation	Rat kidney tissue						18323855
TRPP1	TRPC1	Co-immunoprecipitation		HEK293 tsA 201	Human	Full-length	Human	Full-length	20682256
TRPP1	TRPC1	Co-immunoprecipitation		HEK293T	Human	Full-length	Human	Full-length	10097141
TRPP1	TRPC3	Co-immunofluorescence staining		LLC-PK1	Human	1-697	Not used		19812035
TRPP1	TRPC3	Co-immunoprecipitation		HEK293	Human	1-697	Mouse	Full-length	19812035
TRPP1	TRPC4	Co-immunoprecipitation		Human glomerular mesangial cell	Not used		Bovine	Full-length	18256307
TRPP1	TRPC7	Co-immunoprecipitation		HEK293	Human	1-697	Mouse	Full-length	19812035
TRPP1	TRPV4	Co-immunofluorescence staining	MDCK						18695040
TRPP1	TRPV4	Co-immunoprecipitation		HEK293 tsA 201	Human	Full-length	Mouse	Full-length	20682256
TRPP1	TRPV4	Co-immunoprecipitation		HEK293	Human	C-terminus	Mouse	C-terminus	18695040
TRPP1	TRPV4	Fluorescence resonance energy transfer		HEK293	Human	Full-length	Mouse	Full-length	18695040
TRPP1	UBC	Co-immunoprecipitation	Mouse Inner medullary collecting duct cell						18178578
TRPP1	α-actinin-1	Co-immunofluorescence staining	NIH-3T3						15843396
TRPP1	α-actinin-1	Co-immunofluorescence staining	MDCK						15843396
TRPP1	α-actinin-1	Co-immunofluorescence staining	Mouse inner medullary collecting duct cell						15843396
TRPP1	α-actinin-1	Co-immunoprecipitation	HEK293						15843396
TRPP1	α-actinin-1	Co-immunoprecipitation	MDCK						15843396
TRPP1	α-actinin-1	Co-immunoprecipitation	Rat kidney tissue						15843396
TRPP1	α-actinin-2	Co-immunoprecipitation	Rat heart tissue						15843396
TRPP1	β-Trcp1	Co-immunoprecipitation		HEK293	Mouse	Full-length	Mouse	Full-length	17636028
TRPP1	β-Trcp2	Co-immunoprecipitation		HEK293	Mouse	Full-length	Mouse	Full-length	17636028
TRPP1	γ-adaptin	Co-immunoprecipitation	COS M6 kidney cell						15692563

(

: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening

Validation: In vitro validation

Validation: In vivo validation

Characterization

Functional consequence

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Characterization
			Binding region mapping				Stoichiometry	Affinity (Kd)	Reference
			TRP channel		Interactor
TRP channel	Interactor	Method	Species	Region	Species	Region
TRPP1	CD2AP	Fusion protein-pull down assay	Mouse	747-968	Mouse	331-637			10913159
TRPP1	DIAP1/DRF1	Co-immunoprecipitation	Human	679-968	Mouse	543-1203			15123714
TRPP1	EGFR	Co-immunoprecipitation	Human	1-871	Human	Not determined			16135816
TRPP1	HAX-1	Yeast two-hybrid	Human	618-658	Mouse	179-280			10760273
TRPP1	HERP	Co-immunoprecipitation	Human	1-208	Mouse	Not determined			18178578
TRPP1	HERP	Co-immunoprecipitation	Human	689-968	Mouse	Not determined			18178578
TRPP1	ID2	Yeast two-hybrid	Human	679-968	Human	30-84			16311606
TRPP1	IP3R1	Fusion protein-pull down assay	Human	Not determined	Human	1-345			20375013
TRPP1	KIF3A	Fusion protein-pull down assay	Human	682-968	Human	403-702			17008358
TRPP1	KIF3A	Yeast two-hybrid	Human	872-927	Human	403-702			16950792
TRPP1	KIF3B	Fusion protein-pull down assay	Human	682-968	Human	407-747			17008358
TRPP1	KIF3B	Yeast two-hybrid	Human	1-215	Human	407-747			17008358
TRPP1	KIM1/TIM1	Co-immunoprecipitation	Human	1-30	Human	Not determined			18273441
TRPP1	PACS-1	Fluorescence probe labeling						14.8 μM	15692563
TRPP1	PACS-1	Fusion protein-pull down assay	Human	741-871	Human	115-255			15692563
TRPP1	PACS-2	Fluorescence probe labeling						15.4 μM	15692563
TRPP1	PACS-2	Fusion protein-pull down assay	Human	Not determined	Human	117-266			15692563
TRPP1	PIGEA-14/CBY1	Yeast two-hybrid	Human	680-968	Human	60-112			15194699
TRPP1	PIGEA-14/CBY1	Yeast two-hybrid	Human	833-923	Human	Not determined			15194699
TRPP1	PKD1/Polycystin-1	Co-immunoprecipitation	Human	742-968	Human	4227-4303			11140688
TRPP1	PKD1/Polycystin-1	Co-immunoprecipitation	Human	680-968	Human	1227-1339			9192675
TRPP1	PKD1/Polycystin-1	Fusion protein-pull down assay	Human	681-968	Not specified	4077-4302			15692563
TRPP1	PKD1/Polycystin-1	Fusion protein-pull down assay	Human	833-895	Human	4213-4248			19556541
TRPP1	PKD1/Polycystin-1	Fusion protein-pull down assay	Human	821-927	Mouse	4183-4270			19726544
TRPP1	PKD1/Polycystin-1	Fusion protein-pull down assay	Human	742-872	Human	4214-4248			9171830
TRPP1	PKD1/Polycystin-1	Yeast two-hybrid	Human	742-968	Human	1227-1339			9192675
TRPP1	PKD1/Polycystin-1	Yeast two-hybrid	Human	822-895	Human	4124-4303			10097141
TRPP1	PKD1/Polycystin-1	Yeast two-hybrid	Human	742-872	Human	4214-4248			9171830
TRPP1	PKD1L1/Polycystin-1L1	Co-immunoprecipitation	Mouse	Full-length	Mouse	2440-2607			21307093
TRPP1	PKHD1/FPC	Co-immunoprecipitation	Human	90-139	Human	3903-3964			18782757
TRPP1	PKHD1/FPC	Co-immunoprecipitation	Human	1-221	Human	3872-4074			18235088
TRPP1	PKHD1/FPC	Co-immunoprecipitation	Human	Not determined	Human	3850-4074			17008358
TRPP1	PLCγ2	Co-immunoprecipitation	Human	1-379	Not specified	Not determined			16135816
TRPP1	RyR2	Fusion protein-pull down assay	Human	703-968	Mouse	Not determined			17404231
TRPP1	RyR2	Fusion protein-pull down assay	Human	130-220	Mouse	Not determined			17404231
TRPP1	Syntaxin5	Co-immunoprecipitation	Human	5-72	Mouse	Not determined			18836075
TRPP1	Syntaxin5	Fusion protein-pull down assay	Human	Not determined	Mouse	256-333			18836075
TRPP1	TAZ/WWTR1	Fusion protein-pull down assay	Mouse	678-966	Mouse	220-272			17636028
TRPP1	Tropomyosin 1	Yeast two-hybrid	Human	821-878	Human	152-196			12527301
TRPP1	Troponin I 3	Yeast two-hybrid	Human	872-927	Human	1-107			12525172
TRPP1	Troponin I 3	Yeast two-hybrid	Human	872-927	Human	106-158			12525172
TRPP1	TRPC1	Atomic force microscopy(AFM) analysis					2:2		19850920
TRPP1	TRPC1	Atomic force microscopy(AFM) analysis					2:2		19193631
TRPP1	TRPC1	Co-immunoprecipitation	Human	1-643	Human	Not determined			10097141
TRPP1	TRPC1	Co-immunoprecipitation	Human	679-968	Human	Not determined			10097141
TRPP1	TRPC1	Yeast two-hybrid	Human	822-895	Human	639-750			10097141
TRPP1	TRPC3	Fusion protein-pull down assay	Human	1-697	Mouse	659-753			19812035
TRPP1	TRPV4	Atomic force microscopy(AFM) analysis					2:2		20682256
TRPP1	α-actinin-1	Fusion protein-pull down assay	Human	821-878	Chicken	Not determined			15843396
TRPP1	α-actinin-1	Yeast two-hybrid	Human	821-878	Human	334-892			15843396
TRPP1	α-actinin-2	Fusion protein-pull down assay	Human	821-878	Chicken	Not determined			15843396
TRPP1	α-actinin-2	Yeast two-hybrid	Human	821-878	Human	341-894			15843396
TRPP1	α-actinin-2	Yeast two-hybrid	Human	1-215	Human	341-894			15843396
TRPP1	α-actinin-2	Yeast two-hybrid	Human	1-215	Human	596-728			15843396

(

: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening

Validation: In vitro validation

Validation: In vivo validation

Characterization

Functional consequence

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Functional consequence
TRP channel	Interactor	Method	Post-translational modification	Subcellular trafficking	Activity	Reference
TRPP1	80K-H	Co-immunofluorescence staining		Retain in the endoplasmic reticulum		19801576
TRPP1	KIF3A	Patch clamp			Activation	16950792
TRPP1	PKD1/Polycystin-1	Co-immunofluorescence staining		Increase in plasma membrane level		11140688
TRPP1	PKD1/Polycystin-1	Patch clamp			New channel creation	11140688
TRPP1	Syntaxin5	Patch clamp			Inhibition	18836075
TRPP1	TRPC1	Patch clamp			New channel creation	18323855
TRPP1	TRPV4	Patch clamp			New channel creation	18695040
TRPP1	α-actinin	Patch clamp			Activation	15843396

(

: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

TRIP Database

TRPP1 / interactors