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Casein kinase-mediated phosphorylation of serine 839 is necessary for basolateral localization of the Ca(2)(+)-activated non-selective cation channel TRPM4.
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TRPV6 calcium channel translocates to the plasma membrane via Orai1-mediated mechanism and controls cancer cell survival.
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Nitric oxide and protein kinase G act on TRPC1 to inhibit 11,12-EET-induced vascular relaxation.
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Cellular Zinc Levels Are Modulated by TRPML1-TMEM163 Interaction.
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Unique interweaved microtubule scaffold mediates osmosensory transduction via physical interaction with TRPV1.
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TRPV4, TRPC1, and TRPP2 assemble to form a flow-sensitive heteromeric channel.
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The phosphatidylinositol(4,5)bisphosphate-binding sequence of transient receptor potential channel canonical 4alpha is critical for its contribution to cardiomyocyte hypertrophy.
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Mol Pharmacol |
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Depletion of 14-3-3gamma reduces the surface expression of Transient Receptor Potential Melastatin 4b (TRPM4b) Channels and attenuates TRPM4b-mediated glutamate-induced neuronal cell death.
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Functional and biochemical interaction between PPARalpha receptors and TRPV1 channels: Potential role in PPARalpha agonists-mediated analgesia.
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Helminth induced suppression of macrophage activation is correlated with inhibition of calcium channel activity.
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AKAP150-dependent cooperative TRPV4 channel gating is central to endothelium-dependent vasodilation and is disrupted in hypertension.
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Following OGD/R, annexin 1 nuclear translocation and subsequent induction of apoptosis in neurons are assisted by myosin IIA in a TRPM7 kinase-dependent manner.
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The basal thermal sensitivity of the TRPV1 ion channel is determined by PKCbetaII.
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Transient receptor potential vanilloid 1 activation by dietary capsaicin promotes urinary sodium excretion by inhibiting epithelial sodium channel alpha subunit-mediated sodium reabsorption.
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Local control of TRPV4 channels by AKAP150-targeted PKC in arterial smooth muscle.
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Phosphodiesterase 5 inhibition ameliorates angiontensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity.
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Reciprocal positive regulation between TRPV6 and NUMB in PTEN-deficient prostate cancer cells.
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Activation of mu opioid receptors sensitizes transient receptor potential vanilloid type 1 (TRPV1) via beta-arrestin-2-mediated cross-talk.
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Caspase-11 controls interleukin-1beta release through degradation of TRPC1.
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Heteromeric TRPC3 with TRPC1 formed via its ankyrin repeats regulates the resting cytosolic Ca2+ levels in skeletal muscle.
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The TRPM6 kinase domain determines the Mg.ATP sensitivity of TRPM7/M6 heteromeric ion channels.
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Cooperative interaction of trp melastatin channel transient receptor potential (TRPM2) with its splice variant TRPM2 short variant is essential for endothelial cell apoptosis.
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The Ca2+ channel TRPML3 specifically interacts with the mammalian ATG8 homologue GATE16 to regulate autophagy.
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The TRPM8 channel forms a complex with the 5-HT1B receptor and phospholipase D that amplifies its reversal of pain hypersensitivity.
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TRPV1 channels are functionally coupled with BK(mSlo1) channels in rat dorsal root ganglion (DRG) neurons.
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Orphan receptor GPR179 forms macromolecular complexes with components of metabotropic signaling cascade in retina ON-bipolar neurons.
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TRPP2 and TRPV4 form an EGF-activated calcium permeable channel at the apical membrane of renal collecting duct cells.
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A TRPC1 protein-dependent pathway regulates osteoclast formation and function.
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Systematic screens for proteins that interact with the mucolipidosis type IV protein TRPML1.
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Regulation of store-operated calcium entry by FK506-binding immunophilins.
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Cannabinoid receptor 1 suppresses transient receptor potential vanilloid 1-induced inflammatory responses to corneal injury.
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beta-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel.
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TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation.
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Peptidyl-prolyl isomerase FKBP52 controls chemotropic guidance of neuronal growth cones via regulation of TRPC1 channel opening.
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A pathogenic C terminus-truncated polycystin-2 mutant enhances receptor-activated Ca2+ entry via association with TRPC3 and TRPC7.
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Identification of dimer interactions required for the catalytic activity of the TRPM7 alpha-kinase domain.
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TRPC1 associates with BK(Ca) channel to form a signal complex in vascular smooth muscle cells.
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Functional interaction of the cation channel transient receptor potential vanilloid 4 (TRPV4) and actin in volume regulation.
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Secretogranin III directs secretory vesicle biogenesis in mast cells in a manner dependent upon interaction with chromogranin A.
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TRPC3 controls agonist-stimulated intracellular Ca2+ release by mediating the interaction between inositol 1,4,5-trisphosphate receptor and RACK1.
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Proinflammatory mediators modulate the heat-activated ion channel TRPV1 via the scaffolding protein AKAP79/150.
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TRPP2 and TRPV4 form a polymodal sensory channel complex.
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Orai1 mediates the interaction between STIM1 and hTRPC1 and regulates the mode of activation of hTRPC1-forming Ca2+ channels.
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Nitric oxide-cGMP-protein kinase G pathway negatively regulates vascular transient receptor potential channel TRPC6.
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Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1.
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TRPC1 binds to caveolin-3 and is regulated by Src kinase - role in Duchenne muscular dystrophy.
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Off-response property of an acid-activated cation channel complex PKD1L3-PKD2L1.
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ATP/UTP activate cation-permeable channels with TRPC3/7 properties in rat cardiomyocytes.
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The beta-glucuronidase klotho exclusively activates the epithelial Ca2+ channels TRPV5 and TRPV6.
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Protein kinase A anchoring via AKAP150 is essential for TRPV1 modulation by forskolin and prostaglandin E2 in mouse sensory neurons.
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Pirt, a phosphoinositide-binding protein, functions as a regulatory subunit of TRPV1.
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The human TRPV6 channel protein is associated with cyclophilin B in human placenta.
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Lipid rafts determine clustering of STIM1 in endoplasmic reticulum-plasma membrane junctions and regulation of store-operated Ca2+ entry (SOCE).
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Identification of Nipsnap1 as a novel auxiliary protein inhibiting TRPV6 activity.
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A-kinase anchoring protein mediates TRPV1 thermal hyperalgesia through PKA phosphorylation of TRPV1.
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IP3 sensitizes TRPV4 channel to the mechano- and osmotransducing messenger 5'-6'-epoxyeicosatrienoic acid.
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Diverse properties of store-operated TRPC channels activated by protein kinase C in vascular myocytes.
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Functional requirement for Orai1 in store-operated TRPC1-STIM1 channels.
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Formation of a new receptor-operated channel by heteromeric assembly of TRPP2 and TRPC1 subunits.
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TRPC3 is the erythropoietin-regulated calcium channel in human erythroid cells.
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Kidney injury molecule 1 (Kim1) is a novel ciliary molecule and interactor of polycystin 2.
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Mice lacking Homer 1 exhibit a skeletal myopathy characterized by abnormal transient receptor potential channel activity.
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TRPM4b channel suppresses store-operated Ca2+ entry by a novel protein-protein interaction with the TRPC3 channel.
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Interaction with dopamine D2 receptor enhances expression of transient receptor potential channel 1 at the cell surface.
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RACK1 inhibits TRPM6 activity via phosphorylation of the fused alpha-kinase domain.
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Mediation of angiotensin II-induced Ca2+ signaling by polycystin 2 in glomerular mesangial cells.
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Functional relevance of the de novo coupling between hTRPC1 and type II IP3 receptor in store-operated Ca2+ entry in human platelets.
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Nek8 regulates the expression and localization of polycystin-1 and polycystin-2.
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Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function.
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Interaction of transient receptor potential vanilloid 4, integrin, and SRC tyrosine kinase in mechanical hyperalgesia.
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TRPC3-interacting triadic proteins in skeletal muscle.
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Analysis of TRPC3-interacting proteins by tandem mass spectrometry.
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Intracellular Ca2+ store depletion induces the formation of macromolecular complexes involving hTRPC1, hTRPC6, the type II IP3 receptor and SERCA3 in human platelets.
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The annexin 2-S100A10 complex and its association with TRPV6 is regulated by cAMP/PKA/CnA in airway and gut epithelia.
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Polycystin-2 is regulated by endoplasmic reticulum-associated degradation.
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Stimulus-specific modulation of the cation channel TRPV4 by PACSIN 3.
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SERCA2b and 3 play a regulatory role in store-operated calcium entry in human platelets.
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Interaction between protein kinase D1 and transient receptor potential V1 in primary sensory neurons is involved in heat hypersensitivity.
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The spectrin cytoskeleton influences the surface expression and activation of human transient receptor potential channel 4 channels.
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Mucolipin 1 channel activity is regulated by protein kinase A-mediated phosphorylation.
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Direct binding of alpha-actinin enhances TRPP3 channel activity.
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RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC.
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Vasopressin-induced membrane trafficking of TRPC3 and AQP2 channels in cells of the rat renal collecting duct.
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Snapin, a new regulator of receptor signaling, augments alpha1A-adrenoceptor-operated calcium influx through TRPC6.
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PDZ domain-containing protein as a physiological modulator of TRPV6.
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TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex.
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The first ankyrin-like repeat is the minimum indispensable key structure for functional assembly of homo- and heteromeric TRPC4/TRPC5 channels.
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Functional specialization of beta-arrestin interactions revealed by proteomic analysis.
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STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels.
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Genetic evidence supporting caveolae microdomain regulation of calcium entry in endothelial cells.
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Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2.
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Orai proteins interact with TRPC channels and confer responsiveness to store depletion.
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